Results 181 to 190 of about 264,642 (338)

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody [PDF]

, 2010
Don M. Benson, Courtney E. Bakan, Anjali Mishra, Craig C. Hofmeister, Yvonne A. Efebera, Brian Becknell, Robert A. Baiocchi, Jianying Zhang, Jianhua Yu, Megan Smith, Carli N Greenfield, Pierluigi Porcu, Steven M. Devine, Rinat Rotem‐Yehudar, Gerard Lozanski, John C. Byrd, Michael A. Caligiuri   +16 more
openalex   +1 more source

Glabridin‐Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity

Advanced Science, EarlyView.
Complex 6d could promote tumor immunogenicity by targeting thioredoxin reductase (TrxR) and remodel immunosuppressive microenvironment by the mitogen‐activated protein kinase (MAPK) pathway inhibition simultaneously. This study provides a novel approach to develop metal immunomodulatory agents by designing gold complexes incorporating natural products,
Zhaoran Wang, Meiyu Wang, Qiong Chen, Mengshi Wang, Fuwei Li, Lin Lv, Zhenfan Wen, Zhongren Xu, Yixia Yang, Chunyang Bi, Wukun Liu   +10 more
wiley   +1 more source

Resident Macrophage‐Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor‐Associated Nephrotoxicity

Advanced Science, EarlyView.
Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma, Yang Chen, Qinfan Yao, Yuxi Wang, Nan Ouyang, Fei Han, Guzong Wang, Meifang Wang, Yuan Yuan, Jianghua Chen, Jianzhen Shan, Dajin Chen   +11 more
wiley   +1 more source

INVOLVEMENT OF PD-1/PD-L1 PATHWAY FOR INDUCTION OF SUPPRESSION TO ALLOANTIGEN BY CD4+CD25+ REGULATORY T CELL.

, 2006
NULL AUTHOR_ID
openalex   +1 more source

Telbivudine preserves Th1 cytokine response and down regulates PD-L1 in MHV-3–induced viral hepatitis model [PDF]

, 2010
Zhourui Wu, Weiming Yan, Wei Guo, Yong Zou, H. Wang, Xiaochen Wang, Xuefeng Yang, Yulei Lu, Xiaoping Luo, Qin Ning   +9 more
openalex   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Programmed cell death 1 ligand 1 (CD274; PD-L1; B7-H1) [PDF]

, 2010

openalex   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

PD-L1/PD-1 Signal Deficiency Promotes Allogeneic Immune Responses and Accelerates Heart Allograft Rejection

, 2008
Rui Wang, K. Carper, Frances R. Malone, Yvette Latchman, James D. Perkins, Yaowen Fu, Jorgé Reyes, Wei Li   +7 more
openalex   +1 more source

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source