Does the gut microbiota play a key role in PD-1/PD-L1 blockade therapy? [PDF]
, 2020 Satoshi Watanabe, Toshiaki Kikuchi
openalex +1 more source
, 2021 Angelo Borsarelli Carvalho Brito +2 more
openalex +1 more source
PD-L1 positivity predicts response [PDF]
Nature Reviews Clinical Oncology, 2019 openaire +2 more sources
Advanced Science, EarlyView.Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen +16 more
wiley +1 more source
PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes [PDF]
, 2016 Matthew W. Rosenbaum +4 more
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PCN1 IMPACT of PD-1/PD-L1 Inhibitors on Health Outcomes for Patients with Cancer in South Korea [PDF]
, 2020 Kyung-In Joung +7 more
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Correction: New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms and therapeutic opportunities [PDF]
, 2022 Mengyuan Dai +4 more
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METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation
Advanced Science, EarlyView.METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li +19 more
wiley +1 more source