Results 201 to 210 of about 264,642 (338)

Tumor cell PD-L1 predicts poor local control for rectal cancer patients following neoadjuvant radiotherapy

Cancer Management and Research, 2017
Lingdong Shao,* Qingqin Peng,* Kaixin Du,* Junyan He, Yaping Dong, Xiaoyi Lin, Jinluan Li, Junxin Wu Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, People’s Republic of China *These ...
Shao LD, Peng QQ, Du KX, He JY, Dong YP, Lin XY, Li JL, Wu JX   +7 more
doaj  

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

PD-L1 expression as a prognostic factor for postoperative outcomes in pleural mesothelioma. [PDF]

Transl Lung Cancer Res
Kanayama M, Manabe T, Yoshimatsu K, Nemoto Y, Matsumiya H, Mori M, Takenaka M, Kuroda K, Tanaka F.   +8 more
europepmc   +1 more source

PD1/PD-L1 dependent immunosuppression by huiPS-derived cell population [PDF]

, 2011
Jonathan Pini, Arieh Moussaieff, Emilie Murris, Reuven Shalom-Feuerstein, Isabelle Petit, Daniel Aberdam, Matthieu Rouleau   +6 more
openalex   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

135 PD1/PD-L1 PROTECT FROM INFLAMMATION AND FIBROSIS IN NON-ALCOHOLIC STEATOHEPATITIS

, 2009
Christoph Dorn, Moritz Fleck, E Gäbele, Thomas S. Weiß, C.U. Blank, Claus Hellerbrand   +5 more
openalex   +1 more source

Benefit with anti-PD-L1 [PDF]

Nature Reviews Clinical Oncology, 2016
openaire   +2 more sources

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Computational identification and evaluation of novel PD-L1 inhibitors for cancer immunotherapy. [PDF]

Sci Rep
Manzoor H, Khan MU, Shabbir CA, Rehman R, Alhegaili AS, Ullah MI, Ghanem HB, Alameen AAM.   +7 more
europepmc   +1 more source

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity [PDF]

, 2012
Suzanne L. Topalian, Charles G. Drake, Drew M. Pardoll   +2 more
openalex   +1 more source