Results 201 to 210 of about 265,348 (292)
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
Case report: Robust response to sintilimab in advanced distal cholangiocarcinoma with PD-L1 expression and DNA damage repair [PDF]
Wenguang He +5 more
openalex +1 more source
PD‐L1 co‐stimulation contributes to ligand‐induced T cell receptor down‐modulation on CD8 + T cells [PDF]
Katarzyna Karwacz +6 more
openalex +1 more source
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu +8 more
wiley +1 more source
IL-1β Upregulates PD-L1 in Small Extracellular Vesicle of Endothelial Origin. [PDF]
Gagliardi MC +5 more
europepmc +1 more source
Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao +8 more
wiley +1 more source
Advances in the application of PD-1/PD-L1 immunotherapy for prostate cancer: a review. [PDF]
Hu G, Li Z, Chen Y, Liao H, Zhou S.
europepmc +1 more source

