Results 231 to 240 of about 264,642 (338)

Combination of adoptive cell transfer, anti-PD-L1 and anti-LAG-3 antibodies for the treatment of recurrent tumors [PDF]

, 2013
Stephen R. Goding, Kyle Wilson, Paul A. Antony   +2 more
openalex   +1 more source

Avidity‐Based Capture of PD‐L1‐Expressing Exosomes via Dendrimer–Peptide Conjugates: A Nanoengineered Platform for Enhanced Prediction of Immunotherapy Response

Advanced Science, EarlyView.
This study introduces a dendrimer‐peptide conjugate platform (G7‐pPDL1) for avidity‐based capture of PD‐L1‐expressing exosomes. The system exhibits enhanced binding kinetics and exosome capture efficiency, enabling accurate prediction of immunotherapy outcomes.
Jiah Lee, Dongjun Shin, Chae Yeon Son, Hanbit Kang, Jung Hyun Choi, Hyun Sung Park, Seha Bang, Lucia Kim, Tae Hee Lee, Hyuk Soo Eun, Michael J Poellmann, Woo‐jin Jeong, Dong Hyung Kim, Jun Hyeok Lim, Seungpyo Hong, Jiyoon Bu   +15 more
wiley   +1 more source

PD-L1 Expression in NSCLC: Clouds in a Bright Sky. [PDF]

Int J Mol Sci
Ferrari V, Gal J, Mograbi B, Milano G.
europepmc   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
wiley   +1 more source

Identification of PD-L1-related biomarkers for selecting gastric adenocarcinoma patients for PD-1/PD-L1 inhibitor therapy. [PDF]

Discov Oncol
Li BY, Li HL, Zeng FE, Luan XY, Liu BQ, Wang ZZ, Zhang L, Dong XZ.   +7 more
europepmc   +1 more source

PD-1/PD-L1 Interactions Contribute to Functional T-Cell Impairment in Patients Who Relapse with Cancer After Allogeneic Stem Cell Transplantation

, 2011
Wieger J. Norde, Frans Maas, Willemijn Hobo, Alan J. Korman, Michael Quigley, Michel G.D. Kester, Konnie M. Hebeda, J.H. Frederik Falkenburg, Nicolaas Schaap, Theo M. de Witte, Robbert van der Voort, Harry Dolstra   +11 more
openalex   +1 more source

Intravenous iRGD‐Guided, RBC‐Membrane Camouflaged Lactococcus Lactis Remodels Cold NSCLC and Enhances PD‐1 Blockade

Advanced Science, EarlyView.
This study presents an engineered probiotic platform, iRGD‐mRBC@FOLactis, combining red blood cell membrane cloaking and tumor‐penetrating peptide iRGD for enhanced PD‐1 blockade. The platform improves tumor targeting, immune cell activation and therapeutic efficacy in lung cancer, demonstrating significant promise in overcoming PD‐1/PD‐L1 therapy ...
Chen Chen, Junmeng Zhu, Xiao Liu, Jie Shao, Aoxing Chen, Yi Mei, Xinyin Zhang, Qinyi Chen, Lin Li, Baorui Liu   +9 more
wiley   +1 more source

Circ_0074158 and QKI6: A regulatory axis for PD-L1 ubiquitination and immune evasion in NSCLC. [PDF]

Cancer Immunol Immunother
Zhang H, Liu X, Lei J, Tian F, Liu X, Lv F, Kang S, Lan K, Wang J, Yan X, Ni Y.   +10 more
europepmc   +1 more source

PD-L1 Expression by Neurons Nearby Tumors Indicates Better Prognosis in Glioblastoma Patients [PDF]

, 2013
Yawei Liu, R. Carlsson, Malene Ambjørn, Maruf Hasan, Wiaam Badn, Anna Darabi, Peter Siesjö, Shohreh Issazadeh‐Navikas   +7 more
openalex   +1 more source

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

Advanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang, Huanhuan Huang, Kaizong Huang, Xiaowen Cui, Leilei Wu, Renyu Lin, Zhe Zhao, Hua Chen, Cheng Zheng, Weilin Jin, Song Chen, Jiayan Chen, Yaping Xu, Dongping Wei   +13 more
wiley   +1 more source