Results 311 to 320 of about 264,642 (338)

Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine

Aggregate, EarlyView.
Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang, Yanyu Chen, Shile Wang, Kan Liu, Xing‐Zhong Zhao, Xiaobo Mao, Ben Zhong Tang, Lang Rao   +7 more
wiley   +1 more source

p53 and PD-1/PD-L1 expression contribute to disease progression and are correlated to immune infiltrates in urothelial carcinoma. [PDF]

Sci Rep
Zuo M, Liao Y, He P, Zhu Y, Huang T, Tang J, Fan L, Li X, Zhang N.   +8 more
europepmc   +1 more source

Highly Photoluminescent RGB‐Carbon Dots and Their Integration Applications in Light‐Emitting Diodes and Luminescent Solar Concentrators

Aggregate, EarlyView.
Through precise molar ratio control of o‐phenylenediamine and phytic acid, we prepare tricolor carbon dots with high quantum yields. Their superior optical properties enable the development of tunable LEDs (3033–5493 K), luminescent solar concentrators, and an innovative self‐powered integrated photovoltaic system.
Bin Liu, Genghong Huang, Yaling Wang, Huijie Bai, Suping Jia, Fu‐de Ren, Xinghong Zhang   +6 more
wiley   +1 more source

Discovery of novel disulfide-containing PD-1/PD-L1 inhibitor with in vivo influenza therapeutic efficacy. [PDF]

Sci Rep
Hirata Y, Hayashi K, Kato T, Nagaoka Y, Doi M, Uesato S.   +5 more
europepmc   +1 more source

Macrophage‐derived Extracellular Vesicles Disguised AIEgen/IDO1 Inhibitor Nanoplatform Reactivate “Immune‐Hot” for Photothermal Immunotherapy via Multi‐Dimensionally Reprograms Tumor Microenvironment

Aggregate, EarlyView.
Illustration of A/I@REHM nanoparticles preparation (A) and “ICB ‐ Repolarization ‐ PTT” like Poseidon's trident synergistically anti‐tumor treatment (B). ABSTRACT Reversing the tumor microenvironment (TME) from “cold” to “hot” tumor represents a pivotal strategy to overcome the clinical bottleneck of poor response rates to immunotherapy in solid tumors.
Xue Li, Xianglong Zhao, Yin Zhou, Yu Liu, Yushuo Feng, Yeneng Dai, Ping Gong, Qi Zhao, Ming Dong   +8 more
wiley   +1 more source

Theoretical investigation on PD-L1-In-1 for cancer immunotherapy via density functional theory. [PDF]

Sci Rep
Magar BS, Pudasainee K, Pandey P, Neupane MK, Lamichhane RR, Gurung B, Tripathi K, Adhikari B.   +7 more
europepmc   +1 more source

The Fast‐Growing Field of Cancer Immunotherapy Based on Aggregation‐Induced Emission

Aggregate, EarlyView.
Photoimmunotherapy facilitated by AIEgens represents an emerging cancer treatment that combines high‐performance phototheranostics with immunotherapy to achieve satisfactory antitumor effectiveness, and has recently been developed at a tremendous pace and attracted global interests in the past few years.
Zhijie Lin, Tingting He, Miaomiao Kang, Wei Xie, Dong Wang, Ben Zhong Tang   +5 more
wiley   +1 more source

The association of PD-L1 expression status and the PD-1/PD-L1 inhibitor-related toxicity profile in non-small cell lung cancer. [PDF]

BMC Cancer
Zhu Q, Hu H, OuYang LY, Yang R, Wei WX, Huang P, He XR.   +6 more
europepmc   +1 more source

Regulation of PD-L1 Expression by SAHA-Mediated Histone Deacetylase Inhibition in Lung Cancer Cells. [PDF]

Cancers (Basel)
Natarajan U, Rathinavelu A.
europepmc   +1 more source

Higher proportion of coagulative necrosis and PD-L1⁺ immune cells in splenic tuberculosis. [PDF]

Sci Rep
Dai J, Liu L, Liu J, Liu Y, Wu R, Zhou J, Chen W.   +6 more
europepmc   +1 more source