Results 71 to 80 of about 3,128,138 (270)

Peritoneal dialysis in older adults: evaluation of clinical, nutritional, metabolic outcomes, and quality of life [PDF]

, 2018
The number of older adults requiring dialysis is increasing worldwide, whereas the use of peritoneal dialysis (PD) in this population is lower respect to younger patients, despite the theoretical advantages of PD respect to hemodialysis.
Aceto, Paola, Amabile, MARIA IDA, Bargagli, Matteo, Gnerre Musto, Tania, Group on Geriatric Nephrology of the Italian Society of Nephrology (SIN), Study, Lai, Carlo, Lai, Silvia, Martinez, Andrea, Mastroluca, Daniela, Molfino, Alessio, Testorio, Massimo   +10 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Pain assessment in Indian Parkinson's Disease patients using King's Parkinson's Disease pain scale

Annals of Indian Academy of Neurology, 2020
Background: Pain is a common symptom in Parkinson's disease (PD) patients. Scales to rate pain in PD are marred by several flaws, either not being available in other languages or not specific for PD.
Madhuri Behari, Abhilekh Srivastava, Renu Achtani, Neha Nandal, Rupa Bala Dutta   +4 more
doaj   +1 more source

Central Nervous System Xanthoma Disseminatum: Response to 2CdA in an Adolescent

Case Reports in Pediatrics, 2022
Xanthoma disseminatum is a normolipemic non-Langerhans cell histiocytosis characterized by red-brown rubbery papules of the skin which coalesce into plaque-like lesions with symmetric involvement of face, flexor, and intertriginous areas.
Patrick DeMoss, Nancy Tang, Kristen Yeom, Audris Chiang, Ann L. Marqueling, Michael R. Jeng   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Feedback control for deep brain stimulation for motor disorders

Healthcare Technology Letters, 2020
Deep brain stimulation (DBS) is an effective treatment for many people living with Parkinson's disease (PD). Although the primary treatment for PD is based on medications, disease progression eventually leads to inadequate symptom control.
Hugh J. McDermott, Nicholas C. Sinclair
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Total Harmonic Distortion Measurement of 13-level FCML Inverter for SPWM and THIPWM Method [PDF]

Journal of Electrical and Electronics Engineering, 2022
One of the main problems for flying capacitor multilevel (FCML) inverter is the higher value of total harmonic distortion (THD) with number of capacitors and switching devices.
BHADRA Ananta Bijoy
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source