Results 91 to 100 of about 291,222 (247)

Template_7QER_Homotypic_Cx31_1.pdb

Human homotypic Cx31.1 homology model based on the human Cx26 cryoEM structure (7QER).
openaire   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Bone scan findings of Paget’s disease of bone in patients with VCP Multisystem Proteinopathy 1

Scientific Reports
Multisystem Proteinopathy 1 (MSP1) disease is a rare genetic disorder caused by mutations in the Valosin-Containing Protein (VCP) gene with clinical features of inclusion body myopathy (IBM), frontotemporal dementia (FTD), and Paget’s disease of bone ...
Rod Carlo Agram Columbres, Sarosh Din, Liliane Gibbs, Virginia Kimonis   +3 more
doaj   +1 more source

Conductive Hydrogels for Exogenous Sensing and Cell Fate Control

Advanced Materials, EarlyView.
We engineer electrically conductive hydrogels by combining sulfated glycosaminoglycans with semiconducting polymers. These hydrogels bind bioactive proteins, including growth factors, whose release or retention can be modulated by low‐voltage stimulation. The hydrogels are also integrated as 3D channels in organic electrochemical transistors as part of
Teuku Fawzul Akbar, Carlos Alejandro Jimenez‐Rodriguez, Railia Biktimirova, Ilka Hermes, Thomas Kurth, My Duyen Pham, Mikhail Tsurkan, Jens Friedrichs, Francis L. C. Morgan, Hans Kleemann, Olga Guskova, Uwe Freudenberg, Peter Fratzl, Carsten Werner, Christoph Tondera, Ivan R. Minev   +15 more
wiley   +1 more source

TreeSpider: In‐Canopy Exploration With Tether‐Based Aerial Modular Arms

Advanced Robotics Research, EarlyView.
A tethered drone with perching arms and a 360° ring enables unprecedented maneuverability within dense forest canopies. By dynamically adjusting tether length and decoupling pitch from the frame, it navigates between branches, senses multiple trees, and interacts physically with foliage.
Luca Romanello, Tian Lan, Salaheldin Hassan, Maximilian Leutschafft, Erdem Ekinci, Sophie F. Armanini, Mirko Kovac, Basaran Bahadir Kocer   +7 more
wiley   +1 more source

RCSB Protein Data Bank: supporting research and education worldwide through explorations of experimentally determined and computationally predicted atomic level 3D biostructures

IUCrJ
The Protein Data Bank (PDB) was established as the first open-access digital data resource in biology and medicine in 1971 with seven X-ray crystal structures of proteins.
Stephen K. Burley, Dennis W. Piehl, Brinda Vallat, Christine Zardecki   +3 more
doaj   +1 more source

PDB-Metrics: a web tool for exploring the PDB contents.

Genetics and molecular research : GMR, 2006
PDB-Metrics (http://sms.cbi.cnptia.embrapa.br/SMS/pdb_metrics/index.html) is a component of the Diamond STING suite of programs for the analysis of protein sequence, structure and function. It summarizes the characteristics of the collection of protein structure descriptions deposited in the Protein Data Bank (PDB) and provides a Web interface to ...
Renato, Fileto, Paula R, Kuser, Michel E B, Yamagishi, André A, Ribeiro, Thiago G, Quinalia, Eduardo H, Franco, Adauto L, Mancini, Roberto H, Higa, Stanley R M, Oliveira, Edgard H, Santos, Fabio D, Vieira, Ivan, Mazoni, Sergio A B, Cruz, Goran, Neshich   +13 more
openaire   +1 more source

Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage

Advanced Science, EarlyView.
The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Jianmu Su, Sisheng Zhang, Lidi Liang, Haiyi Bai, Mei Bai, Hanjun He, Yayu Wang, Huan Liu, Xiangxiu Liang, Yu Sun, Hong Wu   +10 more
wiley   +1 more source

Template_7QER_Homotypic_Cx31.pdb

Human homotypic Cx31 homology model based on the human Cx26 cryoEM structure (7QER).
openaire   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source