Results 101 to 110 of about 381,553 (352)

PDB Board Test

, 2023
Validation activity of PDB Boards ...
Lazzaroni, Massimo
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Using D-amino acids as the building blocks for bioactive peptides can dramatically increase their potency. However, simply swapping regular levorotary amino acids for dextrorotary (D)-amino acids alters the peptide surface topology and ...
Michael Garton, Satra Nim, T. Stone, K. Wang, C. Deber, Philip M. Kim   +5 more
semanticscholar   +1 more source

On the evolution of the quality of macromolecular models in the PDB

The FEBS Journal, 2020
Crystallographic models of biological macromolecules have been ranked using the quality criteria associated with them in the Protein Data Bank (PDB).
D. Brzeziński, Z. Dauter, W. Minor, M. Jaskólski   +3 more
semanticscholar   +1 more source

sj-pdb-5-ctc-10.1177_25152564231211976 - Supplemental material for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae

, 2023
Supplemental material, sj-pdb-5-ctc-10.1177_25152564231211976 for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae by Sébastien Leterme, Olivier Bastien, Riccardo Aiese ...
Olivier Bastien (7815), Riccardo Aiese Cigliano (4511068), Sébastien Leterme (17463020), Morgane Michaud (17463023), Alberto Amato (3950006)   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Annotating Macromolecular Complexes in the Protein Data Bank: Improving the FAIRness of Structure Data

Scientific Data, 2023
Macromolecular complexes are essential functional units in nearly all cellular processes, and their atomic-level understanding is critical for elucidating and modulating molecular mechanisms.
Sri Devan Appasamy, John Berrisford, Romana Gaborova, Sreenath Nair, Stephen Anyango, Sergei Grudinin, Mandar Deshpande, David Armstrong, Ivanna Pidruchna, Joseph I. J. Ellaway, Grisell Díaz Leines, Deepti Gupta, Deborah Harrus, Mihaly Varadi, Sameer Velankar   +14 more
doaj   +1 more source

PDB files for exercise Structural superposition of PDB structures

, 2019
PDB files for exercise Structural superposition of PDB structures, the files have been downloaded from the PDB database and slightly adapted for easier resuse in the ...
Alexander Botzki, Alexander Botzki (6091931)   +1 more
core   +1 more source

sj-pdb-6-ctc-10.1177_25152564231211976 - Supplemental material for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae

, 2023
Supplemental material, sj-pdb-6-ctc-10.1177_25152564231211976 for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae by Sébastien Leterme, Olivier Bastien, Riccardo Aiese ...
Olivier Bastien (7815), Riccardo Aiese Cigliano (4511068), Sébastien Leterme (17463020), Morgane Michaud (17463023), Alberto Amato (3950006)   +4 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source