Results 111 to 120 of about 381,553 (352)

Extraction of the polysorbate 20 and 80 fingerprint via generative modeling

International Journal of Pharmaceutics: X
Polysorbate 20 (PS20) and polysorbate 80 (PS80) are essential surfactants used to stabilize biopharmaceutical products, yet their highly heterogeneous mixtures and susceptibility to oxidation and enzymatic hydrolysis complicate routine analysis.
Peter Roelants, Reza Ranjbar Choubeh, Nico Verbeeck, Rabindranath Andujar, Torsten Schultz-Fademrecht, Patrick Garidel, Viktor Gross   +6 more
doaj   +1 more source

Villin PDB file

, 2020
PDB file used for analysis of Villin ...
Stefan Doerr (748688)
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Announcing mandatory submission of PDBx/mmCIF format files for crystallographic depositions to the Protein Data Bank (PDB).

Acta Crystallographica Section D: Structural Biology, 2019
This letter announces that PDBx/mmCIF format files will become mandatory for crystallographic depositions to the Protein Data Bank (PDB).
P. Adams, P. Afonine, Kumaran Baskaran, H. Berman, J. Berrisford, G. Bricogne, David G Brown, S. Burley, Min-Yu Chen, Zu-Kang Feng, C. Flensburg, A. Gutmanas, J. C. Hoch, Yasuyo Ikegawa, Yumiko Kengaku, E. Krissinel, G. Kurisu, Yuhe Liang, D. Liebschner, Lora Mak, J. Markley, N. Moriarty, G. Murshudov, Martin Noble, E. Peisach, Irina Persikova, B. Poon, O. Sobolev, E. Ulrich, S. Velankar, C. Vonrhein, J. Westbrook, M. Wojdyr, M. Yokochi, Jasmine Y. Young   +34 more
semanticscholar   +1 more source

sj-pdb-7-ctc-10.1177_25152564231211976 - Supplemental material for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae

, 2023
Supplemental material, sj-pdb-7-ctc-10.1177_25152564231211976 for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae by Sébastien Leterme, Olivier Bastien, Riccardo Aiese ...
Olivier Bastien (7815), Riccardo Aiese Cigliano (4511068), Sébastien Leterme (17463020), Morgane Michaud (17463023), Alberto Amato (3950006)   +4 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A series of PDB-related databanks for everyday needs

Nucleic Acids Res., 2014
We present a series of databanks (http://swift.cmbi.ru.nl/gv/facilities/) that hold information that is computationally derived from Protein Data Bank (PDB) entries and that might augment macromolecular structure studies.
Wouter G. Touw, Coos A. B. Baakman, Jon Black, T. T. Te Beek, E. Krieger, R. Joosten, G. Vriend   +6 more
semanticscholar   +1 more source

Creative PDB`s (parts databases) [PDF]

, 1998
PDB component property entries and creative picklists can make the schematic entry process and downstream tools such as BOM generation more useful. This presentation will show how creative PDB`s can enhance the design process.
Cote, T.J.
core  

thrombin-Piperidine PDB file

, 2020
PDB file used for thrombin-piperidine ...
Stefan Doerr (748688)
core   +1 more source