Results 111 to 120 of about 326,099 (315)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Study on Triazinethiol Electropolymerized Films Prepared by Cyclic Voltammetry and Galvanostatic on Copper Alloy Surface

International Journal of Electrochemical Science, 2011
Poly (6-N,N-dibutylamino-1,3,5-triazine-2,4-dithiol) nanofilm (PDB) were prepared by cyclic voltammetry and galvanostatic electropolymerization of 6-N,N-dibutylamino-1,3,5-triazine-2,4-dithiol monosodium (DBN) on copper alloy surface.
Yanni Li, Dan Wang, Haining Zhang, Fang Wang   +3 more
doaj   +1 more source

MrXaeroX/M3R-PDB: M3R-PDB 1.0

, 2020
This is the first ...
Alexander
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Optimization of Extraction Process, Structural Characterization and in Vitro Bioactivity of Polysaccharides from Dendrocalamus brandisii Bamboo Shoot Shell

Shipin gongye ke-ji
The extraction process of polysaccharides from Dendrocalamus brandisii bamboo shoot shell (PDB) was optimized by Box-Behnken response surface method, and high performance gel permeation chromatography, ion chromatography, ultraviolet spectroscopy, and ...
Jingjie LIU, Xiaowei PENG, Anna WANG, Wenxi XIA, Changwei CAO, Huan KAN, Yun LIU   +6 more
doaj   +1 more source

Citing a Data Repository: A Case Study of the Protein Data Bank.

PLoS ONE, 2015
The Protein Data Bank (PDB) is the worldwide repository of 3D structures of proteins, nucleic acids and complex assemblies. The PDB's large corpus of data (> 100,000 structures) and related citations provide a well-organized and extensive test set for ...
Yi-Hung Huang, Peter W Rose, Chun-Nan Hsu   +2 more
doaj   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Tryptophan-based fluorescent sensor for selective Cu2+ detection in aqueous media and its docking study for anticancer effects

Results in Chemistry
In this study, an efficient copper (II) chemosensor was introduced. This chemosensor had a different response in fluorescent spectra, and the interaction between Cu2+ and tryptophan hydrazide (TH) was substantiated as a static quencher.
Ghodsi Mohammadi Ziarani, Shikofa Khorrami, Fatemeh Mohajer, Sunil V. Gaikwad, Najibullah Hassani, Alireza Badiei, Siavash Iravani, Rajender S. Varma   +7 more
doaj   +1 more source