Results 121 to 130 of about 344,397 (313)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Data‐Driven Materials Science for Energy‐Sustainable Applications

Advanced Materials, EarlyView.
Data‐driven approaches powered by artificial intelligence are transforming materials discovery for energy sustainability. This review examines how auto‐generated high‐quality materials databases and domain‐specific language models accelerate research in photovoltaics, thermoelectrics, batteries and magnetic materials. Applications involve extraction of
Jacqueline M. Cole
wiley   +1 more source

All‐Amyloid Functional Coacervates

Advanced Materials, EarlyView.
This study introduces an all‐amyloid interfacial complex coacervate technique that employs charge‐mediated or functionalization‐assisted complexation of oppositely charged food protein‐derived amyloid nanofibrils to engineer functional soft constructs across multiple length scales.
Seyyed Alireza Hashemi, Mohammad Peydayesh, Laura Baraldi, Mohammad Arjmand, Raffaele Mezzenga   +4 more
wiley   +1 more source

Bone scan findings of Paget’s disease of bone in patients with VCP Multisystem Proteinopathy 1

Scientific Reports
Multisystem Proteinopathy 1 (MSP1) disease is a rare genetic disorder caused by mutations in the Valosin-Containing Protein (VCP) gene with clinical features of inclusion body myopathy (IBM), frontotemporal dementia (FTD), and Paget’s disease of bone ...
Rod Carlo Agram Columbres, Sarosh Din, Liliane Gibbs, Virginia Kimonis   +3 more
doaj   +1 more source

PDB benchmark alignments

, 2014
Multiple sequence alignments used for the PDB benchmark set. Each fasta file begins with the PDB amino acid sequence pair, with other homologous sequences trimmed to match its length.
Kamisetty, Hetunandan, Baker, David, Ovchinnikov, Sergey, Hetunandan Kamisetty (3319377), David Baker (11642), Sergey Ovchinnikov (3319380)   +5 more
core   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Electron transfer complexes

, 2021
Messori, Luigi, De Zorzi, Rita, Geremia, S., Guerri, A., Gabbiani, Chiara, De March, Matteo, Casini, A., Demitri, N.   +7 more
core   +1 more source

Prepared Protein Structures and Ramachandran plot for A) CK2 kinase (PDB ID: 1JWH), B) Ran-importin β (PDB ID: 1IBR), C) Human nerve growth factor (PDB ID: 1SG1), D) Human survivin structure (PDB ID: 1XOX), E) CRK-II (PDB ID: 2DVJ), F) tRNA dihydrouridine synthase 2 (PDB ID: 4XP7), and G) Human AKR1B10 (PDB ID: 4XZL).

Prepared Protein Structures and Ramachandran plot for A) CK2 kinase (PDB ID: 1JWH), B) Ran-importin β (PDB ID: 1IBR), C) Human nerve growth factor (PDB ID: 1SG1), D) Human survivin structure (PDB ID: 1XOX), E) CRK-II (PDB ID: 2DVJ), F) tRNA ...
Tahani Bakhsh (20037072), Abeer Al Tuwaijri (14693359), Misbahuddin Rafeeq (22403656), Majidah Aljadani (24375549), Hadeel A. Alsufyani (7959881), Najat Binothman (13798900), Alaa Hamed Habib (12472107), Maryam Abdulrahman Alahdal (24375546), Nawal Helmi (9612913), Maryam A. AL-Ghamdi (24375552), Hadil Alahdal (18437292)   +10 more
core   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source