Results 71 to 80 of about 326,099 (315)

Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

eLife, 2021
Paget’s disease of bone (PDB) is characterized by focal increases in disorganized bone remodeling. This study aims to characterize PDB-associated changes in DNA methylation profiles in patients’ blood.
Ilhame Diboun, Sachin Wani, Stuart H Ralston, Omar ME Albagha   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PDB-REPRDB: a database of representative protein chains from the Protein Data Bank (PDB) [PDF]

Nucleic Acids Research, 2001
PDB-REPRDB is a database of representative protein chains from the Protein Data Bank (PDB). The previous version of PDB-REPRDB provided 48 representative sets, whose similarity criteria were predetermined, on the WWW. The current version is designed so that the user may obtain a quick selection of representative chains from PDB.
Tamotsu Noguchi, Hideo Matsuda, Yutaka Akiyama   +2 more
openaire   +2 more sources

Raw diffraction images of pyruvate phosphate dikinase (PPDK), PDB 5JVN

, 2019
<p>Raw diffration images and processing input files/logs of pyruvate phosphate dikinase (PPDK) from the C₃ plant <em>Flaveria pringlei</em>.
Minges, Alexander, Höppner, Astrid, Groth, Georg   +2 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Representation of viruses in the remediated PDB archive [PDF]

Acta Crystallographica Section D Biological Crystallography, 2008
A new scheme has been devised to represent viruses and other biological assemblies with regular noncrystallographic symmetry in the Protein Data Bank (PDB). The scheme describes existing and anticipated PDB entries of this type using generalized descriptions of deposited and experimental coordinate frames, symmetry and frame transformations.
Lawson, Catherine L., Dutta, Shuchismita, Westbrook, John D., Henrick, Kim, Berman, Helen M.   +4 more
openaire   +2 more sources

Structure of MDM2-MDMX-UbcH5B-ubiquitin complex

, 2017
Crystal structure reveal how MDM2-MDMX complex recriuits E2~ubiquitin ...
Vousden, Karen, Huang, Danny, Sibbet, Gary, Hock, Andreas, Nomura, Koji, Kowalczyk, Dominika, Klejnot, Marta   +6 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Extraction of the polysorbate 20 and 80 fingerprint via generative modeling

International Journal of Pharmaceutics: X
Polysorbate 20 (PS20) and polysorbate 80 (PS80) are essential surfactants used to stabilize biopharmaceutical products, yet their highly heterogeneous mixtures and susceptibility to oxidation and enzymatic hydrolysis complicate routine analysis.
Peter Roelants, Reza Ranjbar Choubeh, Nico Verbeeck, Rabindranath Andujar, Torsten Schultz-Fademrecht, Patrick Garidel, Viktor Gross   +6 more
doaj   +1 more source

CELLmicrocosmos 2.2: advancements and applications in modeling of three-dimensional PDB membranes (Conference Abstract)

, 2010
Sommer B, Dingersen T, Schneider S, Rubert S, Gamroth C. CELLmicrocosmos 2.2: advancements and applications in modeling of three-dimensional PDB membranes (Conference Abstract). In: Journal of Cheminformatics. Journal of Cheminformatics.
S Rubert, Schneider, S., Rubert, S., Rubert S, C Gamroth, Dingersen T, Schneider S, Gamroth C, Sommer Björn, T Dingersen, Dingersen, T., Björn Sommer, S Schneider, Sommer, Björn, Gamroth, C.   +14 more
core   +1 more source