Results 71 to 80 of about 344,397 (313)
, 2023 Supplemental material, sj-pdb-7-ctc-10.1177_25152564231211976 for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae by Sébastien Leterme, Olivier Bastien, Riccardo Aiese ...
Olivier Bastien (7815) +4 more
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Monostotic Paget’s disease of bone – literature review and case report
Rheumatology, 2019 Paget’s disease of bone (PDB) is a localized, chronic bone metabolic disorder, characterized by an osteoclastic malfunction, causing increased bone resorption and subsequent compensatory creation of new bone with a defective microstructure.
Piotr Wysiński +1 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scientific Data, 2023 Macromolecular complexes are essential functional units in nearly all cellular processes, and their atomic-level understanding is critical for elucidating and modulating molecular mechanisms.
Sri Devan Appasamy +14 more
doaj +1 more source
Raw diffraction images of pyruvate phosphate dikinase (PPDK), PDB 5JVN
, 2019 <p>Raw diffration images and processing input files/logs of pyruvate phosphate dikinase (PPDK) from the C<sub>3</sub> plant <em>Flaveria pringlei</em>.
Minges, Alexander +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Extraction of the polysorbate 20 and 80 fingerprint via generative modeling
International Journal of Pharmaceutics: XPolysorbate 20 (PS20) and polysorbate 80 (PS80) are essential surfactants used to stabilize biopharmaceutical products, yet their highly heterogeneous mixtures and susceptibility to oxidation and enzymatic hydrolysis complicate routine analysis.
Peter Roelants +6 more
doaj +1 more source
Structure of MDM2-MDMX-UbcH5B-ubiquitin complex
, 2017 Crystal structure reveal how MDM2-MDMX complex recriuits E2~ubiquitin ...
Vousden, Karen +6 more
core +1 more source