Results 91 to 100 of about 222,931 (262)

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Adaptive Uncertainty-Penalized Model Selection for Data-Driven PDE Discovery

IEEE Access
We propose a new parameter-adaptive uncertainty-penalized Bayesian information criterion (UBIC) to discover the stable governing partial differential equation (PDE) composed of a few important terms.
Pongpisit Thanasutives, Takashi Morita, Masayuki Numao, Ken-Ichi Fukui   +3 more
doaj   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma

Respiratory Research, 2004
Background The anti-inflammatory effects of the selective phosphodiesterase (PDE) inhibitors cilostazol (PDE 3), RO 20-1724 (PDE 4) and sildenafil (PDE 5) were examined in a murine model of allergic asthma.
Galbraith Deirdre, Nagasawa Michiaki, Mackenzie Alison, Dick Colin AJ, Clayton Robert A, Hastings Stuart F, MacKenzie Simon J   +6 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Impact of Uncertain Parameters on Navier–Stokes Equations With Heat Transfer via Polynomial Chaos Expansion

International Journal for Numerical Methods in Fluids, EarlyView.
This study investigates the impact of uncertain parameters on Navier–Stokes equations coupled with heat transfer using the Intrusive Polynomial Chaos Method (IPCM). Sensitivity equations are formulated for key input parameters, such as viscosity and thermal diffusivity, and solved numerically using the Finite Element‐Volume method.
N. Nouaime, B. Després, M. A. Puscas, C. Fiorini   +3 more
wiley   +1 more source

The role of phosphodiesterase type-5 inhibitors in treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia

Urology Research and Practice, 2019
Phosphodiesterase type-5 (PDE-5) inhibitors are approved as the first line of therapy for the treatment of erectile dysfunction. However, different studies have been performed to study the use of these agents in other areas of urology.
Mehmet UMUL, Tekin Ahmet SEREL
doaj   +1 more source

Local Polynomial Regression and Filtering for a Versatile Mesh‐Free PDE Solver

International Journal for Numerical Methods in Fluids, EarlyView.
A high‐order, mesh‐free finite difference method for solving differential equations is presented. Both derivative approximation and scheme stabilisation is carried out by parametric or non‐parametric local polynomial regression, making the resulting numerical method accurate, simple and versatile. Numerous numerical benchmark tests are investigated for
Alberto M. Gambaruto
wiley   +1 more source

MULTITIME FLOQUET THEORY

Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2013
This paper is a contribution to the Floquet ideas applied for multitime overdetermined linear first order PDE dynamical systems with multi- periodic coefficients.
Constantin Udrişte
doaj   +1 more source