Results 101 to 110 of about 6,477,427 (341)

Interval Optimization-Based Unit Commitment for Deep Peak Regulation of Thermal Units

open access: yesEnergies, 2019
The deep peak regulation of thermal units is an important measure for coping with significant wind power penetration. In this paper, based on interval optimization, a novel multi-objective unit commitment method is proposed considering the deep peak ...
Yinping Yang   +3 more
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Electricity Capacity Requirements: Who Pays? [PDF]

open access: yes
Reserve requirements in electricity markets may get each producer to internalize the cost of grid-wide blackouts it might cause if unable to meet consumer demand. Markets for how such capacity might be procured have been studied. Less examined is how the
Brennan, Timothy
core  

Using Battery Storage for Peak Shaving and Frequency Regulation: Joint Optimization for Superlinear Gains

open access: yes, 2017
We consider using a battery storage system simultaneously for peak shaving and frequency regulation through a joint optimization framework which captures battery degradation, operational constraints and uncertainties in customer load and regulation ...
Shi, Yuanyuan   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

open access: yes, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon   +54 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Natural Regulation of Energy Flow in a Green Quantum Photocell

open access: yes, 2015
Manipulating the flow of energy in nanoscale and molecular photonic devices is of both fundamental interest and central importance for applications in light harvesting optoelectronics.
Aji, Vivek   +3 more
core   +2 more sources

Optimizing production scheduling of steel plate hot rolling for economic load dispatch under time-of-use electricity pricing [PDF]

open access: yes, 2017
Time-of-Use (TOU) electricity pricing provides an opportunity for industrial users to cut electricity costs. Although many methods for Economic Load Dispatch (ELD) under TOU pricing in continuous industrial processing have been proposed, there are still ...
Duan, Bin   +4 more
core   +3 more sources

Towards a Nigerian objectives based triple peaks financial regulation

open access: yes, 2015
This is a normative research on how best to structure financial regulatory agencies and principles consistently with the core objectives of financial regulation in such a manner that can yield an effective regulatory framework for Nigeria. It moves forward the debate on what an effective financial regulatory ought to be relative to a country's national
Famuyiwa, Kazeem Olumide   +1 more
openaire   +2 more sources

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