Results 111 to 120 of about 6,477,427 (341)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Research on Fast Search Method of Rod Position in Peak Load Regulation of PWR Based on Convolutional Neural Network

Yuanzineng kexue jishu
The rapid expansion of nuclear power in China has led to a significant increase in both operational and under-construction reactor capacity. To ensure grid stability and efficient power consumption, nuclear power plants must engage in peak load ...
MA Chaolong1, ZHANG Jianfu2, BAI Jiahe1, FANG He2, WAN Chenghui1
doaj   +1 more source

Assessing the efficiency of China’s environmental regulation on carbon emissions based on Tapio decoupling models and GMM models

Energy Reports, 2018
This paper takes 30 provinces in China from 2004 to 2015 as research samples, using the Tapio decoupling models, differential GMM methods and peak forecasting models to analyze the effect of environmental regulation on carbon emissions, and subdividing ...
Guo Wenbo, Chen Yan
doaj   +1 more source

Did English Generators Play Cournot? Capacity Withholding in the Electricity Pool [PDF]

, 2004
Electricity generators can raise the price of power by withholding their plant from the market. We discuss two ways in which this could have affected prices in the England and Wales Pool.
Green, Richard J.
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analysis of heat storage technologies and business model in the peak regulation of power grid

Zhejiang dianli
The conventional operation mode of “power determined by heat” employed by thermal power plants， along with the randomness and volatility of new energy power generation， constrains the peak regulation capacity.
YAO Wenzhuo, ZHANG Kang, CHEN Mengdong, MA Meixiu, KANG Wei, CHEN Siyi, HAN Gaoyan   +6 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Optimal Economic Dispatch Strategy for Cascade Hydropower Stations Considering Electric Energy and Peak Regulation Markets

Energies
With the evolution of the power market and the increase in the new energy penetration rate, the power industry will present diversified characteristics.
Fan Liu, Wentao Huang, Jingjing Ma, Jun He, Can Lv, Yukun Yang   +5 more
doaj   +1 more source

Financial Regulation and Supervision in the Euro Area: A Four-Peak Proposal [PDF]

In this paper, we discuss pros and cons of different models for financial market regulation and supervision and we present a proposal for the re-organisation of regulatory and supervisory agencies in the Euro Area.
Carmine Di Noia, Giorgio Di Giorgio
core