Results 131 to 140 of about 495,930 (304)

A Practical Short-run Approach to Market Equilibrium [PDF]

The "short-run approach" calculates long-run producer optima and general equilibria bybuilding on short-run solutions to the producer's profit maximization problem and onprofit-based valuation of the fixed inputs. We outline this method and illustrate it
Anthony Horsley, Andrew J Wrobel
core  

On a Hypercycle System with Nonlinear Rate

, 2001
We study an (N+1)-hypercyclical reaction-diffusion system with nonlinear reaction rate n. It is shown that there exists a critical threshold N_0 such that for N\leq N_0 the system is stable while for N> N_0 it becomes unstable.
Winter, M, Juncheng Wei, Matthias Winter, Wei, J   +3 more
core   +1 more source

Enhancing operational planning of active distribution networks considering effective topology selection and thermal energy storage

iEnergy
Grid-scale energy storage systems provide effective solutions to address challenges such as supply-load imbalances and voltage violations resulting from the non-coinciding nature of renewable energy generation and peak demand incidents. While battery and
Vineeth Vijayan, Ali Arzani, Satish M. Mahajan   +2 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Existence, classification and stability analysis of multiple-peaked solutions for the gierer-meinhardt system in R^1

, 2007
We consider the Gierer-Meinhardt system in R^1. where the exponents (p, q, r, s) satisfy 1< \frac{ qr}{(s+1)( p-1)} < \infty, 1
Winter, M, Wei, J
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Peak solutions for an elliptic system of FitzHugh-Nagumo type

, 2010
The aim of this paper is to study the existence of various types of peak solutions for an elliptic system of FitzHugh-Nagumo type. We prove that the system has a single peak solution, which concentrates near the boundary of the domain.
Dancer, Edward Norman, Yan, Shusen
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multi-Peak Solutions to Two Types of Free Boundary Problems

, 2014
We consider the existence of multi-peak solutions to two types of free boundary problems arising in confined plasma and steady vortex pair under conditions on the nonlinearity we believe to be almost optimal.
Peng, Shuangjie, Li, Yi
core   +1 more source