Results 121 to 130 of about 4,142,971 (284)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Regional Solutions coordinators
, 2017 "State resources are strategically aligned throughout Oregon to accomplish these goals [of community and economic development] though Regional Solutions Advisory Committees, Centers, and Teams...Coordination for these is provided by the Governor's Office"
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2014 Southern Oregon AVA; Rogue Valley AVABear Creek Growing AreaGrizzly Peak Winery's rack card, describing the vineyard, the winery and tasting room as well as the varietals.Grizzly Peak Winery is nestled on the slopes of Grizzly Peak, in Ashland, Oregon ...
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Mixed interior and boundary peak solutions of the Neumann problem for the Henon equation in R^2
Electronic Journal of Differential Equations, 2015 Let $\Omega$ be a bounded domain in $\mathbb{R}^2$ with smooth boundary and $0\in\overline{\Omega}$, we study the Neumann problem for the Henon equation $$\displaylines{ -\Delta u+u=|x|^{2\alpha}u^p,\quad u>0 \quad \text{in } \Omega,\cr \frac ...
Yibin Zhang, Haitao Yang
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Applied SciencesTransmission tower guy wires are critical flexible tension members ensuring the stability and safe operation of overhead power transmission networks. However, these components are vulnerable to external impacts from falling rocks, ice masses, and other ...
Jin-Gang Yang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2011 Southern Oregon AVA; Rogue Valley AVABear Creek Growing AreaSeveral of Grizzly Peak's 2010 and 2011 vintagesGrizzly Peak Winery is nestled on the slopes of Grizzly Peak, in Ashland, Oregon.
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