Results 111 to 120 of about 1,624,486 (300)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Achieving Ultra-Low Latency in 5G Millimeter Wave Cellular Networks
, 2016 The IMT 2020 requirements of 20 Gbps peak data rate and 1 millisecond latency present significant engineering challenges for the design of 5G cellular systems.
Dutta, Sourjya +5 more
core +1 more source
Single-peak and multi-peak solutions for Hamiltonian elliptic systems in dimension two
arXiv admin note: text overlap with arXiv:2205 ...
Zhang, Hui +3 more
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 1992 We here calculate the one-loop approximation to the Euclidean Quantum Gravity coupled to a scalar field around the classical Carlini and Miji\'c wormhole solutions.
Carlini, Alberto, Martellini, Maurizio
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Construction of single-peak solutions for Grushin equations via reduction method
Electronic Journal of Differential EquationsIn this article, we construct single-peak solutions for a class of Grushin equations by using the Lyapunov-Schmidt reduction method, whose concentration points locate on some special critical points of the potential function.
Yawei Wei, Xiaodong Zhou
doaj
Research on pulse electrodeposition of Fe-Ni alloy
AIP Advances, 2014 Fe-Ni alloys were fabricated on steel substrates by means of pulse electrodeposition in sulfate solutions. The layers were electrodeposited using different peak current densities, duty cycles and frequencies.
Yongsen Peng +4 more
doaj +1 more source
Intensity limits for stationary and interacting multi-soliton complexes
, 2001 We obtain an accurate estimate for the peak intensities of multi-soliton complexes for a Kerr-type nonlinearity in the (1+1) - dimension problem. Using exact analytical solutions of the integrable set of nonlinear Schrodinger equations, we establish a ...
Akhmediev +18 more
core +1 more source