Results 61 to 70 of about 495,930 (304)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Peaked and Smooth Solitons for K*(4,1) Equation
Journal of Applied Mathematics, 2013 This paper is contributed to explore all possible single peak solutions for the K*(4,1) equation ut=uxu2+2α(uuxxx+2uxuxx). Our procedure shows that the K*(4,1) equation either has peakon, cuspon, and smooth soliton solutions when sitting on a nonzero ...
Yongan Xie, Hualiang Fu, Shengqiang Tang
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Spikes for the two-dimensional Gierer-Meinhardt system: The weak coupling case
, 2001 In this paper, we rigorously prove the existence and stability of multiple-peaked patterns for the singularly perturbed Gierer-Meinhardt system in a two dimensional domain which are far from spatial homogeneity.
Winter, M, Wei, J
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
On the Gierer-Meinhardt System with Saturation
, 2004 We consider the following shadow Gierer-Meinhardt system with saturation: \left\{\begin{array}{l} A_t=\epsilon^2 \Delta A -A + \frac{A^2}{ \xi (1+k A^2)} \ \ \mbox{in} \ \Omega \times (0, \infty),\\ \tau \xi_t= -\xi +\frac{1}{|\Omega|} \int_\Om A^2 ...
Winter, M, Wei, J
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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On the Stationary Cahn-Hilliard Equation: Bubble Solutions
, 1998 We study stationary solutions of the Cahn--Hilliard equation in a bounded smooth domain which have an interior spherical interface (bubbles). We show that a large class of interior points (the ``nondegenerate peak'' points) have the following ...
Winter, M +3 more
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On the number of single-peak solutions of the nonlinear Schrödinger equation
Annales de l'Institut Henri Poincaré C, Analyse non linéaire, 2002 In this paper we consider uniqueness and multiplicity results for single-peak solutions for the nonlinear Schrödinger equation. For a suitable class of potentials V and critical points P we are able to establish exact multiplicity ...
openaire +4 more sources