Results 71 to 80 of about 1,624,486 (300)

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multi-interior-spike solutions for the Cahn-Hilliard equation with arbitrarily many peaks [PDF]

, 2000
We study the Cahn-Hilliard equation in a bounded smooth domain without any symmetry assumptions. We prove that for any fixed positive integer K there exist interior $K$--spike solutions whose peaks have maximal possible distance from the boundary ...
Wei, J, Winter, M
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The Cole-Cole Law for Critical Dynamics in Glass-Forming Liquids

, 2006
Within the mode-coupling theory (MCT) for glassy dynamics, the asymptotic low-frequency expansions for the dynamical susceptibilities at critical points are compared to the expansions for the dynamic moduli; this shows that the convergence properties of ...
A. P. Singh, L. Sjögren, M. Fuchs, Matthias Sperl   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multi-peak solutions for a class of degenerate elliptic equations

, 2003
By means of a penalization argument due to del Pino and Felmer, we prove the existence of multi-spike solutions for a class of quasilinear elliptic equations under natural growth conditions. Compared with the semilinear case some difficulties arise, mainly concerning the properties of the limit equation.
GIACOMINI, Alessandro, SQUASSINA M.
openaire   +6 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Multi-Objective Residential Load Scheduling Approach Based Pelican Optimization Algorithm with Multi-Criteria Decision Making

Journal of Engineering and Sustainable Development
The existing energy grid faces challenges in meeting the escalating energy demands driven by annual population growth and the proliferation of energy-consuming devices in the contemporary era.
Hiba Haider, Haider Tarish
doaj   +1 more source

Analysis of the Evolution of Tannic Acid Stabilized Gold Nanoparticles Using Mie Theory

International Journal of Analytical Chemistry, 2014
Spherical gold nanoparticles (GNPs) have been synthesized in aqueous solutions using sodium citrate (SC) and tannic acid (TA) as reducing and stabilizing agents.
Assia Rachida Senoudi, Sidi Mohammed Chabane Sari, Ilhem Faiza Hakem   +2 more
doaj   +1 more source