Results 81 to 90 of about 11,472 (199)
Eliciting dose is associated with tolerance development in peanut and cow’s milk allergic children
Clinical and Translational Allergy, 2019 Background Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the reported prevalence rates. Little
C. Nitsche +5 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT Background IgE‐mediated food allergy burdens individuals, families and healthcare systems. Randomised controlled trials indicate early introduction and regular consumption of common food allergens in infancy can reduce food allergy risk. Few studies have explored parental and healthcare professional experiences. This systematic review examines
Karen Wright +14 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan +5 more
wiley +1 more source
Allergy, EarlyView.Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider +48 more
wiley +1 more source
Allergy, EarlyView.Soy lecithin and DATEM, the two commonly used food emulsifiers introduced into many foods including peanut butter and puffed bread, in the 2000s, impair intestinal epithelial barrier integrity in human gut‐on‐a‐chip and induced pluripotent stem cell colon organoid models.
Duygu Yazici +22 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT Allergen immunotherapy (AIT) has been acknowledged as the only disease‐modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study results may vary substantially.
Roy Gerth van Wijk +10 more
wiley +1 more source
Human IgE Antibodies Recognize the Vicilin and Alpha‐Hairpinin Domains of Peanut Allergen Ara h 1
Allergy, EarlyView.The ɑ‐hairpinin of Ara h 1 contains a dominant epitope that is both frequently recognized and blocks a majority of the IgE against this domain. Including this region in tests may improve diagnosis of peanut allergy. The trimeric structure of the vicilin region explains the ability of Ara h 1 to induce anaphylaxis with a single antibody.
Taylor M. Cosey +14 more
wiley +1 more source
Asthma Remission From Childhood to Young Adulthood–A Population‐Based Cohort Study
Allergy, EarlyView.Among 257 participants with asthma at age 8 years, 39% achieved symptom‐based remission by age 24, 29% achieved clinical remission, and 18% achieved complete remission. Male sex increased the likelihood of symptom‐based remission, while food sensitization and overweight/obesity decreased the likelihood.
Lina Broström +6 more
wiley +1 more source
The External Exposome and Food Allergy: How Environmental Exposures Shape Disease Risk
Allergy, EarlyView.ABSTRACT IgE‐mediated food allergy is a global health issue with rising prevalence that cannot be explained by genetic change alone, strongly suggesting that environmental exposures are a key driver. The external exposome encompasses several exposures that influence the developing immune system and modify food allergy risk.
Johanna M. Smeekens +5 more
wiley +1 more source