Results 21 to 30 of about 2,167 (210)

Using singlet oxygen to synthesise the CDE-ring system of the pectenotoxins [PDF]

Org. Biomol. Chem., 2012
A non-classical route to the key CDE-ring fragment of the pectenotoxins has been developed which showcases a remarkable singlet oxygen-mediated cascade reaction sequence to install the complete DE ring system.This is the accepted version of the published
Montagnon, Tamsyn, Vassilikogiannakis, Georgios, Kalaitzakis, Dimitris, Kouridaki, Antonia   +3 more
core   +4 more sources

Sublethal exposure of eastern oyster Crassostrea virginica to the goniodomin-producing dinoflagellate Alexandrium monilatum: Fate of toxins, histopathology, and gene expression. [PDF]

J Aquat Anim Health
Abstract Objective The dinoflagellate Alexandrium monilatum forms blooms during summer in tributaries of the lower Chesapeake Bay. Questions persist about the potential for A. monilatum to negatively affect aquatic organisms. Its main toxin, goniodomin A (GDA), a polyketide macrolide, has been shown to have adverse effects on animals, for example ...
Gaillard S, Small HJ, Carnegie RB, Harris TM, Tanniou S, Réveillon D, Hess P, Reece KS.   +7 more
europepmc   +2 more sources

Mortality and histopathology in sheepshead minnow (Cyprinodon variegatus) larvae exposed to pectenotoxin-2 and Dinophysis acuminata.

Aquatic Toxicology, 2023
Toxic species of the dinoflagellate genus Dinophysis can produce diarrheic toxins including okadaic acid (OA) and dinophysistoxins (DTXs), and the non-diarrheic pectenotoxins (PTXs).
S. Gaillard, D. Réveillon, P. L. Mason, N. Ayache, M. Sanderson, J. Smith, S. Giddings, P. McCarron, V. Séchet, H. Hégaret, P. Hess, W. K. Vogelbein   +11 more
semanticscholar   +1 more source

Comparison of cytotoxicity among pectenotoxin-2 and other oxidized pectenotoxins in a rat myoblast cell line (L6) and a human rhabdomyosarcoma cell line (RD)

Fundamental Toxicological Sciences, 2015
Toshiyuki Suzuki, Hajime Uchida, Ryoji Matsushima   +2 more
exaly   +2 more sources

Optimization and Validation of a High Throughput UHPLC-MS/MS Method for Determination of the EU Regulated Lipophilic Marine Toxins and Occurrence in Fresh and Processed Shellfish

Marine Drugs, 2022
Under the name of lipophilic marine toxins, there are included more than 1000 toxic secondary metabolites, produced by phytoplankton, with the common chemical property of lipophilicity.
Teresa D’Amore, Sonia Lo Magro, Valeria Vita, Aurelia Di Taranto   +3 more
doaj   +1 more source

Interplay of cascade oxidative cyclization and hydride shifts in the synthesis of the ABC spiroketal ring system of pectenotoxin-4.

Angewandte Chemie, 2013
Concepts: The formation of stereochemically defined bis-THF units through a double cyclization and a hydride-shift-initiated route to spiroketals is described (see scheme; Xc=chiral auxiliary).
T. Donohoe, Radosław Lipiński
semanticscholar   +2 more sources

Correction to: Detection of the phycotoxin pectenotoxin-2 in waters around King George Island, Antarctica

Polar Biology, 2021
A correction to this paper has been published: https://doi.org/10.1007/s00300-021-02834 ...
B. Krock, I. Schloss, N. Trefault, U. Tillmann, M. Hernando, D. Deregibus, J. Antoni, G. Almandoz, M. Hoppenrath   +8 more
semanticscholar   +1 more source

A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis

Angewandte Chemie, Volume 134, Issue 27, July 4, 2022., 2022
The dinuclear RuII complex [(Ru(phen)2)2(tpphz)]4+ binds to G‐actin monomers, preventing assembly into F‐actin. This inhibits actin fibre assemblies within live cells and causes disruption to late cytokinesis by interfering with the function of endosomal sorting complexes required for transport (ESCRT) during abscission.
Martin R. Gill, Paul J. Jarman, Vanessa Hearnden, Simon D Fairbanks, Marcella Bassetto, Hannes Maib, John Palmer, Kathryn R. Ayscough, Jim A. Thomas, Carl Smythe   +9 more
wiley   +2 more sources

Cultures of Dinophysis sacculus, D. acuminata and pectenotoxin 2 affect gametes and fertilization success of the Pacific oyster, Crassostrea gigas.

Environmental Pollution, 2020
Harmful algal blooms (HABs) of toxic species of the dinoflagellate genus Dinophysis are a threat to human health as they are mainly responsible for diarrheic shellfish poisoning (DSP) in the consumers of contaminated shellfish.
S. Gaillard, N. L. Le Goïc, Florent Malo, M. Boulais, C. Fabioux, Lucas Zaccagnini, L. Carpentier, Manoella Sibat, D. Réveillon, V. Séchet, P. Hess, H. Hégaret   +11 more
semanticscholar   +1 more source

First detection of pectenotoxin-2 in shellfish associated with an intense spring bloom of Dinophysis acuminata on the central Chilean coast.

Marine Pollution Bulletin, 2020
Diarrhetic shellfish poisoning (DSP) toxins and pectenotoxins (PTX) produced by endemic species of the genus Dinophysis, mainly D. acuta and D. acuminata, pose a big threat to public health, artisanal fisheries and the aquaculture industry in Southern ...
Patricio A. Díaz, Gonzalo Álvarez, M. Seguel, Andrés Marín, B. Krock   +4 more
semanticscholar   +1 more source