Results 91 to 100 of about 13,973,138 (276)

Improved understanding of physics processes in pedestal structure, leading to improved predictive capability for ITER

, 2013
Joint experiment/theory/modelling research has led to increased confidence in predictions of the pedestal height in ITER. This work was performed as part of a US Department of Energy Joint Research Target in FY11 to identify physics processes that ...
R. Groebner, C. S. Chang, J. Hughes, R. Maingi, P. Snyder, X. Xu, J. Boedo, Dennis P. Boyle, James D. Callen, J. Canik, I. Cziegler, E. Davis, A. Diallo, Patrick H Diamond, J. Elder, D. Eldon, D. Ernst, D. Fulton, M. Landreman, A. Leonard, J. Lore, T. Osborne, A. Pankin, S. Parker, T. Rhodes, Sterling Smith, A. Sontag, W. Stacey, J. Walk, W. Wan, E. Wang, J. Watkins, Anne White, D. Whyte, Zheng Yan, E. Belli, B. Bray, J. Candy, R. Churchill, T. Deterly, E. Doyle, M. Fenstermacher, N. Ferraro, A. Hubbard, I. Joseph, J. Kinsey, B. LaBombard, C. Lasnier, Zhihong Lin, B. Lipschultz, Chunshan Liu, Y. Ma, G. Mckee, D. Ponce, J. Rost, L. Schmitz, G. Staebler, L. Sugiyama, J. L. Terry, M. Umansky, R. Waltz, S. M. Wolfe, L. Zeng, S. Zweben   +63 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Identification of a window for quiescent H-mode operation in MHD stability diagram of DIII-D plasmas

Nuclear Fusion
A window for quiescent H-mode (QH-mode) operation in DIII-D plasmas in the diagram of pedestal magnetohydrodynamic (MHD) stability was identified through linear MHD stability analysis, accounting for the effects of plasma rotation and ion diamagnetic ...
N. Aiba, X. Chen, T.H. Osborne, K.H. Burrell   +3 more
doaj   +1 more source

Preparation of Chitosan Microflower and Factors Affecting Its Morphology [PDF]

Shipin Kexue
Chitosan (CS) was dissolved with the aid of ultrasound and hydrogen peroxide treatment. Then, sodium tripolyphosphate (TPP) was introduced as a crosslinker into CS solution from bottom to top.
JIAO Siyu, XU Dingyu, YAO Xianchao, HE Lixin, LIN Rihui
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Design of a Transcription-based Secretion Activity Reporter (TSAR) for the Type III Secretion Apparatus of Shigella flexneri and Uses Thereof

Bio-Protocol, 2014
Many gram-negative bacterial pathogens, including Shigella flexneri, are able to translocate bacterial proteins, dubbed effectors, across the host cell plasma membrane into the host cell cytosol using a syringe-like structure, the type three secretion ...
Francois Campbell-Valois, Pamela Schnupf, Philippe Sansonetti   +2 more
doaj   +1 more source