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Pediatric Acute Liver Failure [PDF]

Pediatric Reports, 2023
Pediatric acute liver failure (PALF) has recently become a subject of great interest when multiple clusters of non-A to non-E severe acute hepatitis in otherwise healthy young children with a median age of 2 years were reported around the world [...]
Claudia Mandato, Pietro Vajro
doaj   +4 more sources

Prognostic Markers in Pediatric Acute Liver Failure [PDF]

GE: Portuguese Journal of Gastroenterology, 2023
Introduction: Acute liver failure (ALF), although rare in children, is a complex progressive pathology, with multisystem involvement and high mortality.
Andreia Filipa Nogueira, Catarina Teixeira, Carla Fernandes, Rita Moinho, Isabel Gonçalves, Carla Regina Pinto, Leonor Carvalho   +6 more
doaj   +5 more sources

Pediatric Acute Liver Failure in Sickle Cell Disease [PDF]

GE: Portuguese Journal of Gastroenterology, 2021
Introduction: Sickle cell intrahepatic cholestasis (SCIC) is one of the rarest and the most severe acute hepatic manifestations of sickle cell disease (SCD) and it can rapidly progress to acute liver failure.
Luís Rodrigues, Sofia Almeida, Catarina Salgado, Cristina Gonçalves   +3 more
doaj   +5 more sources

Pediatric acute liver failure: An experience of a pediatric intensive care unit from resource limited settings [PDF]

Frontiers in Pediatrics, 2022
IntroductionPediatric acute liver failure is a rare and serious disease. Though liver transplantation is considered as the established treatment option for patients who are unlikely to recover with medical management, however, with the advancement of ...
Puja Amatya, Sudeep Kumar Kapalavai, Akash Deep, Srinivas Sankaranarayanan, Ravikumar Krupanandan, Kalaimaran Sadasivam, Bala Ramachandran   +6 more
doaj   +2 more sources

Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes [PDF]

mBio
In 2022, a cluster of severe childhood hepatitis was detected primarily in Europe and North America, leading to a global alert by the World Health Organization.
Ruben H. de Kleine, Ellen C. Carbo, Willem S. Lexmond, Xuewei W. Zhou, Alicia de Kroon, Hailiang Mei, Sander T. H. Bontemps, Rick Hennevelt, Lilli Gard, Igor A. Sidorov, Stefan A. Boers, Marius C. van den Heuvel, Emilie P. Buddingh, Aloys C. M. Kroes, Vincent E. de Meijer, Elisabeth H. Schölvinck, Karin J. von Eije, Simon P. Jochems, Jutte J. C. de Vries   +18 more
doaj   +2 more sources

Genetic landscape of pediatric acute liver failure of indeterminate origin. [PDF]

Hepatology, 2023
Background and Aims: Pediatric acute liver failure (PALF) is a life-threatening condition. In Europe, the main causes are viral infections (12%–16%) and inherited metabolic diseases (14%–28%). Yet, in up to 50% of cases the underlying etiology remains elusive, challenging clinical management, including liver transplantation. We
Lenz D, Schlieben LD, Schlieben LD, Shimura M, Bianzano A, Smirnov D, Smirnov D, Kopajtich R, Berutti R, Adam R, Aldrian D, Baric I, Baumann U, Bozbulut NE, Brugger M, Brunet T, Bufler P, Burnytė B, Calvo PL, Crushell E, Dalgiç B, Das AM, Dezsőfi A, Distelmaier F, Fichtner A, Freisinger P, Garbade SF, Gaspar H, Goujon L, Hadzic N, Hartleif S, Hegen B, Hempel M, Henning S, Hoerning A, Houwen R, Hughes J, Iorio R, Iwanicka-Pronicka K, Jankofsky M, Junge N, Kanavaki I, Kansu A, Kaspar S, Kathemann S, Kelly D, Kirsaçlioğlu CT, Knoppke B, Kohl M, Kölbel H, Kölker S, Konstantopoulou V, Krylova T, Kuloğlu Z, Kuster A, Laass MW, Lainka E, Lurz E, Mandel H, Mayerhanser K, Mayr JA, McKiernan P, McClean P, McLin V, Mention K, Müller H, Pasquier L, Pavlov M, Pechatnikova N, Peters B, Petković Ramadža D, Piekutowska-Abramczuk D, Pilic D, Rajwal S, Rock N, Roetig A, Santer R, Schenk W, Semenova N, Sokollik C, Sturm E, Taylor RW, Tschiedel E, Urbonas V, Urreizti R, Vermehren J, Vockley J, Vogel GF, Wagner M, van der Woerd W, Wortmann SB, Zakharova E, Hoffmann GF, Meitinger T, Murayama K, Staufner C, Prokisch H.   +96 more
europepmc   +16 more sources

Timing of liver transplantation for pediatric acute liver failure due to mushroom poisoning: a case report and literature review [PDF]

BMC Pediatrics, 2020
Background Pediatric acute liver failure is a rare, life-threatening illness. Mushroom poisoning is a rare etiology. For patients with irreversible pediatric acute liver failure, liver transplantation is the ultimate lifesaving therapy.
Chun-Feng Yang, Chu-Qiao Sheng, Yu Ao, Yu-Mei Li   +3 more
doaj   +2 more sources

Development of a prognostic model for pediatric acute liver failure in a Brazilian center [PDF]

Jornal de Pediatria, 2022
Objective: Pediatric acute liver failure (PALF) is a heterogeneous, rare, and severe condition, which outcome is survival due to liver spontaneous recovery or death.
José Colleti Junior, Ana Cristina Aoun Tannuri, Uenis Tannuri, Artur Figueiredo Delgado, Werther Brunow de Carvalho   +4 more
doaj   +2 more sources

Outcomes Analyses of Pediatric Acute Liver Failure Subjects Listed for Liver Transplantation. [PDF]

J Pediatr Gastroenterol Nutr, 2022
ABSTRACTBackground:We characterized recent outcomes in US pediatric acute liver failure (PALF) subjects listed for liver transplantation (LT) using the Scientific Registry of Transplant Recipients (SRTR) database.Methods:Pediatric subjects listed for LT from 2002 to 2015 were assigned to the “PALF” group based on status 1/1A listing, INR >2, no ...
Kulkarni SS, Goss CW, Khan AS, Nadler ML, Stoll JM, Doyle MB, Turmelle YP, Rudnick DA.   +7 more
europepmc   +3 more sources

Hemostatic Balance in Pediatric Acute Liver Failure: Epidemiology of Bleeding and Thrombosis, Physiology, and Current Strategies [PDF]

Frontiers in Pediatrics, 2020
Pediatric Acute Liver Failure (PALF) is a rapidly progressive clinical syndrome encountered in the pediatric ICU which may rapidly progress to multi-organ dysfunction, and on occasion to life threatening cerebral edema and hemorrhage.
Yonca Bulut, Anil Sapru, Gavin D. Roach
doaj   +2 more sources