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Pediatric Acute Liver Failure [PDF]

Pediatric Reports, 2023
Pediatric acute liver failure (PALF) has recently become a subject of great interest when multiple clusters of non-A to non-E severe acute hepatitis in otherwise healthy young children with a median age of 2 years were reported around the world [...]
Claudia Mandato, Pietro Vajro
doaj   +4 more sources

Prognostic Markers in Pediatric Acute Liver Failure [PDF]

GE: Portuguese Journal of Gastroenterology, 2023
Introduction: Acute liver failure (ALF), although rare in children, is a complex progressive pathology, with multisystem involvement and high mortality.
Andreia Filipa Nogueira, Catarina Teixeira, Carla Fernandes, Rita Moinho, Isabel Gonçalves, Carla Regina Pinto, Leonor Carvalho   +6 more
doaj   +6 more sources

Pediatric acute liver failure: An experience of a pediatric intensive care unit from resource limited settings [PDF]

Frontiers in Pediatrics, 2022
IntroductionPediatric acute liver failure is a rare and serious disease. Though liver transplantation is considered as the established treatment option for patients who are unlikely to recover with medical management, however, with the advancement of ...
Puja Amatya, Sudeep Kumar Kapalavai, Akash Deep, Srinivas Sankaranarayanan, Ravikumar Krupanandan, Kalaimaran Sadasivam, Bala Ramachandran   +6 more
doaj   +4 more sources

Pediatric Acute Liver Failure in Sickle Cell Disease [PDF]

GE: Portuguese Journal of Gastroenterology, 2021
Introduction: Sickle cell intrahepatic cholestasis (SCIC) is one of the rarest and the most severe acute hepatic manifestations of sickle cell disease (SCD) and it can rapidly progress to acute liver failure.
Luís Rodrigues, Sofia Almeida, Catarina Salgado, Cristina Gonçalves   +3 more
doaj   +5 more sources

Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes [PDF]

mBio
In 2022, a cluster of severe childhood hepatitis was detected primarily in Europe and North America, leading to a global alert by the World Health Organization.
Ruben H. de Kleine, Ellen C. Carbo, Willem S. Lexmond, Xuewei W. Zhou, Alicia de Kroon, Hailiang Mei, Sander T. H. Bontemps, Rick Hennevelt, Lilli Gard, Igor A. Sidorov, Stefan A. Boers, Marius C. van den Heuvel, Emilie P. Buddingh, Aloys C. M. Kroes, Vincent E. de Meijer, Elisabeth H. Schölvinck, Karin J. von Eije, Simon P. Jochems, Jutte J. C. de Vries   +18 more
doaj   +2 more sources

Genetic landscape of pediatric acute liver failure of indeterminate origin. [PDF]

Hepatology, 2023
Background and Aims: Pediatric acute liver failure (PALF) is a life-threatening condition. In Europe, the main causes are viral infections (12%–16%) and inherited metabolic diseases (14%–28%). Yet, in up to 50% of cases the underlying etiology remains elusive, challenging clinical management, including liver transplantation. We
Lenz D, Schlieben LD, Schlieben LD, Shimura M, Bianzano A, Smirnov D, Smirnov D, Kopajtich R, Berutti R, Adam R, Aldrian D, Baric I, Baumann U, Bozbulut NE, Brugger M, Brunet T, Bufler P, Burnytė B, Calvo PL, Crushell E, Dalgiç B, Das AM, Dezsőfi A, Distelmaier F, Fichtner A, Freisinger P, Garbade SF, Gaspar H, Goujon L, Hadzic N, Hartleif S, Hegen B, Hempel M, Henning S, Hoerning A, Houwen R, Hughes J, Iorio R, Iwanicka-Pronicka K, Jankofsky M, Junge N, Kanavaki I, Kansu A, Kaspar S, Kathemann S, Kelly D, Kirsaçlioğlu CT, Knoppke B, Kohl M, Kölbel H, Kölker S, Konstantopoulou V, Krylova T, Kuloğlu Z, Kuster A, Laass MW, Lainka E, Lurz E, Mandel H, Mayerhanser K, Mayr JA, McKiernan P, McClean P, McLin V, Mention K, Müller H, Pasquier L, Pavlov M, Pechatnikova N, Peters B, Petković Ramadža D, Piekutowska-Abramczuk D, Pilic D, Rajwal S, Rock N, Roetig A, Santer R, Schenk W, Semenova N, Sokollik C, Sturm E, Taylor RW, Tschiedel E, Urbonas V, Urreizti R, Vermehren J, Vockley J, Vogel GF, Wagner M, van der Woerd W, Wortmann SB, Zakharova E, Hoffmann GF, Meitinger T, Murayama K, Staufner C, Prokisch H.   +96 more
europepmc   +15 more sources

Management of Acute Liver Failure: A Pediatric Perspective [PDF]

Current Pediatrics Reports, 2018
Pediatric acute liver failure is a rare, complex, rapidly progressing, and life-threatening illness. Majority of pediatric acute liver failures have unknown etiology. This review intends to discuss the current literature on the challenging aspects of management of acute liver failure.Collaborative multidisciplinary approach for management of patients ...
Girish Rao
exaly   +3 more sources

Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. [PDF]

PLoS ONE, 2013
Tools to predict death or spontaneous survival are necessary to inform liver transplantation (LTx) decisions in pediatric acute liver failure (PALF), but such tools are not available.
Nabil Azhar, Cordelia Ziraldo, Derek Barclay, David A Rudnick, Robert H Squires, Yoram Vodovotz, Pediatric Acute Liver Failure Study Group   +6 more
doaj   +3 more sources

Timing of liver transplantation for pediatric acute liver failure due to mushroom poisoning: a case report and literature review [PDF]

BMC Pediatrics, 2020
Background Pediatric acute liver failure is a rare, life-threatening illness. Mushroom poisoning is a rare etiology. For patients with irreversible pediatric acute liver failure, liver transplantation is the ultimate lifesaving therapy.
Chun-Feng Yang, Chu-Qiao Sheng, Yu Ao, Yu-Mei Li   +3 more
doaj   +2 more sources

Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study group [PDF]

Journal of Pediatrics, 2006
To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors.A prospective, multicenter case study collecting demographic, clinical, laboratory, and short-term outcome data on children from birth to 18 years with ALF.
Simon Horslen, Brendan Mcguire, Saul Karpen   +2 more
exaly   +3 more sources