Results 91 to 100 of about 51,344 (275)

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Etiology, outcome and prognostic factors of childhood acute liver failure in a German Single Center

Annals of Hepatology, 2015
Pediatric acute liver failure (PALF) is a progressive, potentially fatal clinical syndrome occurring in previously healthy children. Our study aimed to determine the current leading causes of PALF in a single center in Germany, identifying possible ...
Simone Kathemann, Lars P. Bechmann, Jan-Peter Sowa, Paul Manka, Alexander Dechêne, Patrick Gerner, Elke Lainka, Peter F. Hoyer, Ariel E. Feldstein, Ali Canbay   +9 more
doaj   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Assessment of Prognostic Factors of Acute Hepatitis Among Pediatric Patients: A Cross‐Sectional Study

JGH Open
Introduction Early identification of acute hepatitis etiology and specific management is crucial for reducing morbidity and mortality. Therefore, this study aims to investigate the prognostic factors of acute hepatitis in children.
Neda Ezoddin, Fateme Ziamanesh, Alireza Ramandi, Pejman Rohani, MohammadHassan Sohouli, Hosein Alimadadi   +5 more
doaj   +1 more source

Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient

Frontiers in Pediatrics
IntroductionHemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that can lead to multiorgan failure, including acute liver failure.
Filipa Paixão, André Salvada, Susana Santos, Catarina Amorim, Carlos Escobar   +4 more
doaj   +1 more source

Fallo hepático aguda asociado a enfermedades metabólicas hereditarias en niños pequeños

Anales de Pediatría, 2018
Resumen: Introducción: El fallo hepático agudo (FHA) secundario a enfermedades metabólicas hereditarias (EMH) es una enfermedad grave infrecuente de mal pronóstico. La intervención temprana puede salvar vidas. Objetivo: Describir la presentación clínica,
Filipa Dias Costa, Rita Moinho, Sandra Ferreira, Paula Garcia, Luísa Diogo, Isabel Gonçalves, Carla Pinto   +6 more
doaj   +1 more source

Image_2_Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C.jpeg

, 2022
Background: We describe the first pediatric case of a 10-month-old boy with MIS-C who developed fulminant acute liver failure with associated giant cell transformation and a fatal outcome, after ruling out other infectious, metabolic, genetic, and ...
Berlly Lucia Diaz Gómez (11984549), Rocio Plazas Pachón (11984543), Marcela Hincapié Echeverría (11984540), Paola Mora Umaña (11984546), Nathalie Gualdron Barreto (11984552), Carolina Bonilla Gonzalez (11728065)   +5 more
core   +1 more source

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source

Intensive Care for Acute Liver Failure in Pediatric Practice (Review)

Общая реаниматология
Acute liver failure (ALF) is a rare pathologic syndrome in pediatric practice with a high risk of multiple organ failure and death. Despite extensive research on risk factors and clinical manifestations, there are no standardized critical care protocols ...
G. A. Avakyan, Yu. V. Bykov, A. N. Obedin   +2 more
doaj   +1 more source

Fatal acute myocarditis and fulminant hepatic failure in an infant with pandemic human influenza A, H1N1 (2009) virus infection

Journal of Advanced Research, 2011
We report the clinical presentation of a 10 month-old infant who succumbed with acute myocarditis and fulminant hepatic failure associated with a virologically confirmed human influenza A, H1N1 (2009) virus infection. To date, this is the first pediatric
Mortada H.F. El-Shabrawi, Hafez M. Bazaraa, Hanan Zekri, Hanaa I. Rady   +3 more
doaj   +1 more source