Results 81 to 90 of about 4,180,741 (282)

Association Between Serum Zinc Levels and Hepatic Encephalopathy in Pediatric decompensated Liver diseases: A Case control Study

Zagazig University Medical Journal
Background: Hepatic encephalopathy (HE) is a serious complication of pediatric liver failure. Zinc plays an important role in ammonia metabolism, but its association with HE in children remains unclear.
Ahmed Mahmoud, Maha El-Bassuoni, Aya Hamad, Marwa Rizk   +3 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Acute-on-chronic liver failure: a review

, 2014
Luis Eduardo Zamora Nava,1 Jonathan Aguirre Valadez,2 Norberto C Chávez-Tapia,3 Aldo Torre21Department of Endoscopy, 2Department of Gastroenterology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, 3Obesity and ...
Zamora Nava LE, Torre A, Aguirre Valadez J, Chávez-Tapia NC   +3 more
core  

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Pediatric chronic liver failure-sequential organ failure assessment score and outcome of acute liver failure in children

Clinical and Experimental Hepatology, 2020
Liver transplantation remains the only definitive treatment for children with acute liver failure proven to have irreversible liver injury. Many prognostic models have been used for outcome prediction in pediatric acute liver failure to select patients in a real need of liver transplantation, but unfortunately all have shown inconsistent ...
Ayoub, Bassam Abdel Hakam, Ali, Mohammed Abdel Hafez, Salem, Tahany Abdel Hamid, Rizk, Marwa Sabry, Nagi, Salma Abdel Megeed, Adawy, Nermin Mohammed   +5 more
openaire   +2 more sources

Acute liver failure after recommended doses of acetaminophen in patients with myopathies

, 2011
Objective: To determine the likelihood that recommended doses of acetaminophen are associated with acute liver failure in patients with myopathies. Design: Retrospective analysis. Setting: Level III pediatric intensive care unit.
Ceelie, I. (Ilse), Shinya Ito, Tibboel, Dick, Ron A. A. Mathot, Gijsen, V.M.G.J. (Violette), Coranne D. Tesselaar, Tesselaar, Coranne D., Mathot, RAA, Koren, G, Laura P. James, Mathôt, R.A.A. (Ron), Koren, Gideon, James, L.P. (Laura), Ilse Ceelie, Tibboel, D. (Dick), Gideon Koren, Mathot, Ron A. A., Dick Tibboel, Wildt, S.N. (Saskia) de, Koren, G. (Gideon), James, Laura P., Ito, Shinya, Saskia N. de Wildt, Ceelie, Ilse, Gijsen, Violette, Tesselaar, C.D. (Coranne), Violette Gijsen, Tesselaar, CD (Coranne), Ito, S. (Shinya), Ito, S, de Wildt, Saskia, de Wildt, Saskia N., James, LP   +32 more
core   +1 more source

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure [PDF]

, 2018
Objective: Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and liver inflammation with massive infiltration of myeloid cells in necrotic areas.
Curbishley, S.M., Khamri, W., Patel, V.C., Pop, O.T., Wilson, I.D., Triantafyllou, E., Ma, Y., Davies, S.P., Dargue, R., Abeles, R.D., Bernsmeier, C., Coen, M., Antoniades, C.G., Liaskou, E., Woollard, K.J., Adams, D.H., Petts, G., Wilhelm, A., Tickle, J., Wendon, J., Stamataki, Z., Possamai, L.A., Weston, C.J., Thursz, M.R., Quaglia, A., Yuksel, M., Singanayagam, A.   +26 more
core   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source