Results 51 to 60 of about 4,767,425 (261)

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices

Nature Communications
BCL-2 is a central regulator of apoptosis and inhibits cell death by sequestering pro-apoptotic BH3 alpha-helices within a hydrophobic surface groove. While venetoclax, a BH3-mimetic drug, has transformed the treatment of BCL-2–driven malignancies, its ...
Thomas M. DeAngelo, Utsarga Adhikary, Kyle J. Korshavn, Hyuk-Soo Seo, Clara R. Brotzen-Smith, Christina M. Camara, Sirano Dhe-Paganon, Gregory H. Bird, Thomas E. Wales, Loren D. Walensky   +9 more
doaj   +1 more source

Neurodevelopmental Consequences of Pediatric Cancer and Its Treatment: The Role of Sleep

Brain Sciences, 2020
Cognitive impairment is frequent in pediatric cancer, and behavioral and psychological disturbances often also affect children who have survived cancer problems. Furthermore, pediatric tumors are also often associated with sleep disorders.
Maria Paola Mogavero, Oliviero Bruni, Lourdes M. DelRosso, Raffaele Ferri   +3 more
doaj   +1 more source

Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau, Kimberly Buff, Michele A. Scialla, Kimberly S. Canter, Lori Wiener, Victoria Sardi‐Brown, Julia B. Tager, Kamyar Arasteh, Anne E. Kazak   +8 more
wiley   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

Predictors of mortality of pediatric cancer patients admitted to the intensive care unit in a low-middle-income country

Frontiers in Pediatrics
BackgroundAdvancements in cancer therapies have markedly increased survival rates among patients. However, this progress has also led to a growing number of pediatric cancer patients requiring admission to intensive care units due to the severity of ...
Rana Helmy, Reham Khedr, Reham Khedr, Youssef Madney, Youssef Madney, Mohamed Kamal, Mark W. Kieran, Ali Mostafa, Ali Mostafa, Alaa Elhaddad, Alaa Elhaddad   +10 more
doaj   +1 more source

Childhood, adolescent and young adult cancer: cancer trends report

, 2023
This is the third Cancer Trends Report the National Cancer Registry Ireland (NCRI) has published on childhood cancers and the first to include cancers in adolescents and young adults (AYA) (up to 24 years of age).
National Cancer Registry Ireland (NCRI)
core  

Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham, Teyl Engstrom, Peter Baade, Natalie Bradford, Sarah Pont, Louise Marquart‐Wilson, Natasha Nassar, Jason D. Pole   +7 more
wiley   +1 more source

Preclinical Development of Bivalent Chimeric Antigen Receptors Targeting Both CD19 and CD22

Molecular Therapy: Oncolytics, 2018
Despite high remission rates following CAR-T cell therapy in B-ALL, relapse due to loss of the targeted antigen is increasingly recognized as a mechanism of immune escape.
Haiying Qin, Sneha Ramakrishna, Sang Nguyen, Thomas J. Fountaine, Anusha Ponduri, Maryalice Stetler-Stevenson, Constance M. Yuan, Waleed Haso, Jack F. Shern, Nirali N. Shah, Terry J. Fry   +10 more
doaj   +1 more source