Results 31 to 40 of about 4,767,425 (261)

Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α

Journal of Neuroinflammation, 2022
Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Approximately one-third of MB patients remain incurable. Understanding the molecular mechanism of MB tumorigenesis is, therefore, critical for developing specific and ...
Biao Gong, Duancheng Guo, Chaonan Zheng, Zhen Ma, Jie Zhang, Yanghui Qu, Xinhua Li, Gen Li, Li Zhang, Yuan Wang   +9 more
doaj   +1 more source

An ethical imperative : safety and specialization as nursing priorities of WHO Global Initiative for Childhood Cancer [PDF]

, 2019
CITATION: Pergert, P., et al. 2019. An ethical imperative : safety and specialization as nursing priorities of WHO Global Initiative for Childhood Cancer. Pediatric Blood & Cancer, 67(4):e28143, doi:10.1002/pbc.28143.The original publication is available
Afungchwi, Glenn Mbah, Pernilla Pergert, Hollis, Rachel, Julia Downing, Adde, Melissa, Melissa Adde, Downing, Julia, Ilbawi, Andre, Julia Challinor, Pergert, Pernilla, Morrissey, Lisa, Glenn Mbah Afungchwi, André Ilbawi, Courtney E. Sullivan, Rehana Punjwani, Challinor, Julia, Rachel Hollis, Punjwani, Rehana, Sullivan, Courtney E., Lisa Morrissey, Downing, J, Punjwani, R, Ilbawi, A, Adde, M, Challinor, J, Hollis, R, Afungchwi, GM, Sullivan, CE, Morrissey, L, Pergert, P,   +29 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Modified BFM-95 chemotherapy with Rituximab in high-risk pediatric advanced- stage mature B-cell non- Hodgkin lymphoma : a single institution experience. [PDF]

ERU Research Journal
Malignant lymphomas represent one of the most common childhood cancers. Advanced-stage mature B-cell lymphomas show aggressive behavior with widespread involvement. Rituximab has improved outcomes in high-risk patients.
Amany Ali, Hany Sayed, Radwa Hussien, Hossam kamel, Ahmed Morsy   +4 more
doaj   +1 more source

The RASopathies: from pathogenetics to therapeutics

Disease Models & Mechanisms, 2022
The RASopathies are a group of disorders caused by a germline mutation in one of the genes encoding a component of the RAS/MAPK pathway. These disorders, including neurofibromatosis type 1, Noonan syndrome, cardiofaciocutaneous syndrome, Costello ...
Katie E. Hebron, Edjay Ralph Hernandez, Marielle E. Yohe   +2 more
doaj   +1 more source

Parent-centered communication at time of pediatric cancer diagnosis: A systematic review

, 2018
There are limited data focused on parental communication needs surrounding the time when a child is diagnosed with cancer. In this systematic review, we synthesized current literature on communication preferences of parents at the time of their child's ...
Nerissa S. Bauer, Erika R. Cheng, Cheng, Erika R., Hentea, Cristiana, Mueller, Emily L., Bauer, Nerissa S., Cristiana Hentea, Emily L. Mueller   +7 more
core   +1 more source

Pediatric cancer pathology review from a single institution: Neuropathology expert opinion is essential for accurate diagnosis of pediatric brain tumors [PDF]

, 2018
Background and objectives: Second pathology review has been reported to improve accuracy in oncologic diagnoses, including pediatric malignancies. We assessed the impact of second review on the diagnosis of pediatric malignancies at a tertiary care ...
Jeha, Sima S., El-Solh, Hassan, Tarek, Nidale, Merabi, Zeina, Boulos, Fouad I., Zaatari, Ghazi S., Jenkins, Jesse Jay, Santiago, Teresa C.B., Muwakkit, Samar A., Abboud, Miguel Raul, Saab, Raya H.   +10 more
core   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source