Results 71 to 80 of about 6,542,588 (257)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Correction to: "Long-Acting Growth Hormone Therapy in Pediatric Growth Hormone Deficiency: A Consensus Statement".

J Clin Endocrinol Metab
europepmc   +2 more sources

Growth Hormone Deficiency in a Patient with Becker Muscular Dystrophy: A Pediatric Case Report [PDF]

Case Reports in Endocrinology, 2013
Objective. To describe a biochemical growth hormone (GH) deficiency and to evaluate therapeutic result in a six-year-old male with Becker muscular dystrophy (BMD).Methods. GH peak was evaluated after response to arginine and insulin. Bone age was evaluated according to Greulich and Pyle method.Results. The GH-supplementary therapy was very effective in
CALCATERRA, VALERIA, BOZZOLA, MAURO, LARIZZA, DANIELA, Malvezzi A., Toglia R., Berardinelli A., Bozzola E.   +6 more
openaire   +4 more sources

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Adherence and Patient Satisfaction in Children Receiving Long-Acting vs. Daily Growth Hormone Therapy: A Single-Center Study

International Journal of Pediatrics & Adolescent Medicine
Objectives Growth hormone deficiency (GHD) in children is a significant medical condition that impairs growth and development, necessitating early intervention to mitigate potential long-term health consequences. This study aimed to assess aspects of the
Nouf M. Alnosani, Abdulmoein Al-Agha
doaj   +1 more source

Pediatric growth hormone deficiency: Understanding the patient and caregiver perspectives

Growth Hormone & IGF Research
Childhood growth hormone deficiency (GHD) is a rare disorder associated with significant burden on both patients and caregivers. Although previous reports have detailed aspects of the burden experienced by patients and their caregivers, there is a paucity of first-hand information on the patient and caregiver journeys from their respective voices.
Bradley S, Miller, Nicky, Kelepouris, Harlan, Tenenbaum, Sonia, Di Carlo, Philippe, Backeljauw   +4 more
openaire   +2 more sources

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Pituitary Morphology and Function in 43 Children with Central Diabetes Insipidus

International Journal of Endocrinology, 2016
Objective. In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed. This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI ...
Wendong Liu, Limin Wang, Minghua Liu, Guimei Li   +3 more
doaj   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Childhood-onset growth hormone deficiency and the transition to adulthood: current perspective

Therapeutics and Clinical Risk Management, 2018
M Ahmid, SF Ahmed, MG Shaikh Development Endocrinology Research Group, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK Abstract: Childhood-onset growth hormone deficiency (CO-GHD) is an endocrine condition associated with ...
Ahmid M, Ahmed SF, Shaikh MG
doaj