Results 21 to 30 of about 1,413,284 (292)

Dual-energy computed tomography to detect early pulmonary vascular changes in children with sickle cell disease: a pilot study

Frontiers in Pediatrics, 2023
IntroductionPulmonary hypertension (PH) is a rare but fatal complication of sickle cell disease (SCD) that is possibly reversible if treated early. Dual-energy computed tomography (DECT) is a valuable tool for diagnosing PH.
Raphael Joye, Raphael Joye, Julie Wacker, Julie Wacker, Duy-Anh Nguyen, Anne-Lise Hachulla, Anne-Lise Hachulla, Albane B. R. Maggio, Laurent Cimasoni, Frederic Lador, Frederic Lador, Marc Ansari, Marc Ansari, Maurice Beghetti, Maurice Beghetti   +14 more
doaj   +1 more source

Speckle Tracking Echocardiographic Ventricular Functions In Infants With Pulmonary Hypertension With Shunt Disease [PDF]

Zagazig University Medical Journal, 2020
Background: Pulmonary arterial hypertension (PAH) is a major complication of congenital heart disease (CHD), it occurs in patients with congenital cardiac shunts with increased morbidity and mortality.
sabry Tolba, soad shedeed, Hassan Mosbah
doaj   +1 more source

Pediatric subcutaneous treprostinil site maintenance and pain control strategies from the Pediatric Pulmonary Hypertension Network

Pulmonary Circulation, 2021
Pulmonary arterial hypertension is a chronic, progressive, and life-threatening disease in children with diverse causes of pulmonary arterial hypertension.
Emma O. Jackson, Anna Brown, Julia McSweeney, Claire Parker   +3 more
doaj   +1 more source

Case report: High-dose epoprostenol therapy in pediatric patients with pulmonary hypertension and developmental lung disease

Frontiers in Pediatrics, 2023
Pulmonary hypertension (PH) with developmental lung disease is a life-threatening disease and accounts for 10%–12% of pediatric PH patients. Administration of specific pulmonary vasodilators to pediatric PH patients has brought about improvement of their
Yoshie Fukasawa, Hidenori Yamamoto, Miharu Ito, Miharu Ito, Akiko Saito, Akiko Saito, Kiyotaka Go, Yoshihito Morimoto, Kazushi Yasuda, Yoshiaki Sato, Masahiro Hayakawa, Taichi Kato   +11 more
doaj   +1 more source

Repurposing of medications for pulmonary arterial hypertension [PDF]

, 2020
This manuscript on drug repurposing incorporates the broad experience of members of the Pulmonary Vascular Research Institute’s Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical industry and regulatory ...
Spiekerkoetter, Edda, Bogaard, Harm Jan, Toshner, Mark, Georg Hansmann, Edda Spiekerkoetter, Harm Bogaard, Hansmann, Georg, Kurt W. Prins, Sylvia Nikkho, Nikkho, Sylvia, Prins, Kurt W., Mark Toshner   +11 more
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Comparison of intravenous sildenafil with inhaled nitric oxide for acute vasodilator testing in pulmonary arterial hypertension

Pulmonary Circulation, 2022
Acute vasodilator testing (AVT) identifies acute responders for initiation of calcium channel blockers in pulmonary arterial hypertension (PAH) and operability in congenital heart disease (CHD).
Shine Kumar, Danish Memon, Manu Raj, Amitabh C. Sen, Jessin P. Jayasankar, Sreelakshmi P. Leeladharan, Abish Sudhakar, Raman K. Kumar   +7 more
doaj   +1 more source

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
core   +2 more sources

Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. [PDF]

, 2005
BACKGROUND: Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur.
Shakur, B Haleema, Paul J Robinson, Morrell, Nicholas W, Peter G Phillips, Shakur B Haleema, Matthew A Higham, B Haleema Shakur, Robinson Paul J, Nicholas W Morrell, Ray J Beddoes, Robinson, Paul J, Beddoes, Ray J, Beddoes Ray J, Higham, Matthew A, Phillips Peter G, Phillips, Peter G, Higham Matthew A, Morrell Nicholas W   +17 more
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Palliative balloon atrial septostomy in two pediatric patients with severe pulmonary arterial hypertension requiring extracorporeal membrane oxygenation support

Pulmonary Circulation, 2020
Pulmonary arterial hypertension is a pernicious disease with a diverse etiology in the pediatric population. Despite the increased availability of drug therapies, pulmonary arterial hypertension continues to cause significant morbidity and mortality.
Samantha L. Brackett, Nina Deutsch, Chinwe Unegbu   +2 more
doaj   +1 more source

Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. [PDF]

, 2003
BACKGROUND\ud \ud Mutations of the transforming growth factor beta (TGFbeta) receptor components ENDOGLIN and ALK-1 cause the autosomal dominant vascular disorder hereditary haemorrhagic telangiectasia (HHT).
Flanagan, J A, Gruenig, E, Sankelo, M, Halme, M, Elliott, C G, Laitinen, T, Morrell, N W, Trembath, R C, Räisänen-Sokolowski, A, Olschewski, H, Harrison, R E, Robbins, I M, Kermeen, F, Abdalla, S A, Rowell, J, Machado, R D, McLaughlin, V   +16 more
core   +1 more source