Results 11 to 20 of about 211,807 (284)

Post-Transcriptional Dysregulation by miRNAs Is Implicated in the Pathogenesis of Gastrointestinal Stromal Tumor [GIST] [PDF]

, 2013
peer-reviewedIn contrast to adult mutant gastrointestinal stromal tumors [GISTs], pediatric/wild-type GISTs remain poorly understood overall, given their lack of oncogenic activating tyrosine kinase mutations.
Hans-Ulrich Schildhaus, J. Keith Killian, Katherine A. Janeway, Kenneth Bryan, Lee Helman, Lorna Kelly, Maria Debiec-Rychter, Markku Miettinen, Matt van de Rijn, Maureen O’Sullivan, null null, Paul S. Meltzer, Su Young Kim   +12 more
core   +11 more sources

Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody

Molecular Therapy: Oncolytics, 2023
Phosphatase of regenerating liver 3 (PRL3) is a specific tumor antigen overexpressed in a broad range of adult cancer types. However, its physiological expression in pediatric embryonal and mesenchymal tumors and its association with clinical outcomes in
Amos Hong Pheng Loh, Min Thura, Abhishek Gupta, Sheng Hui Tan, Kelvin Kam Yew Kuan, Koon Hwee Ang, Khurshid Merchant, Kenneth Tou En Chang, Hui Yi Yon, Yong Chen, Mathew Hern Wang Cheng, Arjandas Mahadev, Matthew Chau Hsien Ng, Michaela Su-Fern Seng, Prasad Iyer, Pei Ling Chia, Shui Yen Soh, Qi Zeng   +17 more
doaj   +1 more source

Epigenomics and immunotherapeutic advances in pediatric brain tumors

npj Precision Oncology, 2021
Brain tumors are the leading cause of childhood cancer-related deaths. Similar to adult brain tumors, pediatric brain tumors are classified based on histopathological evaluations. However, pediatric brain tumors are often histologically inconsistent with
Malak Abedalthagafi, Nahla Mobark, May Al-Rashed, Musa AlHarbi   +3 more
doaj   +1 more source

The role of particle radiotherapy in the treatment of skull base tumors

Frontiers in Oncology, 2023
The skull base is an anatomically and functionally critical area surrounded by vital structures such as the brainstem, the spinal cord, blood vessels, and cranial nerves.
Alberto Iannalfi, Giulia Riva, Lucia Ciccone, Ester Orlandi   +3 more
doaj   +1 more source

The Current Status and Future Potential of Theranostics to Diagnose and Treat Childhood Cancer

Frontiers in Oncology, 2020
In theranostics (i.e., therapy and diagnostics) radiopharmaceuticals are used for both therapeutic and diagnostic purposes by targeting one specific tumor receptor.
Alex J. Poot, Alex J. Poot, Marnix G. E. H. Lam, Max M. van Noesel   +3 more
doaj   +1 more source

Measurement of Apparent Diffusion Coefficient (ADC) Values of Ependymoma and Medulloblastoma Tumors: a Patient-based Study [PDF]

Journal of Biomedical Physics and Engineering, 2021
Background: Some brain tumors such as ependymoma and Medulloblastoma have similar MR images which may result to undifferentiated them from each other.
H Taheri, M B Tavakoli
doaj   +1 more source

Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives [PDF]

, 2003
While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant.
Biagi, Ettore, Bollard, Catherine, Brenner, Malcolm, Rousseau, Raphael   +3 more
core   +5 more sources

Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study. [PDF]

, 2020
BackgroundPoor socioeconomic and health-related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals.
Armstrong, Gregory T, Buerki, Robin A, Chen, Yan, Fullerton, Heather J, Howell, Rebecca, Kline, Cassie N, Krull, Kevin R, Leisenring, Wendy M, Mueller, Sabine, Oeffinger, Kevin C, Robison, Leslie L, Yasui, Yutaka   +11 more
core   +2 more sources

Management of germ cell tumors in children: Approaches to cure [PDF]

, 2002
The introduction of cisplatinum chemotherapy and current advances in the surgical treatment have resulted in a dramatic improvement of the prognosis of children with malignant germ cell tumors (GCT).
Calaminus, G., Göbel, U., Haas, R. J., Schmidt, P., Schneider, D. T.   +4 more
core   +1 more source

Molecular subgroups of adult medulloblastoma: a long-term single-institution study [PDF]

, 2016
Background Recent transcriptomic approaches have demonstrated that there are at least 4 distinct subgroups in medulloblastoma (MB); however, survival studies of molecular subgroups in adult MB have been inconclusive because of small sample sizes. The aim
Ai, Lin, GIANGASPERO, FELICE, Li, Chunde, Li, Peng, Liu, Pinan, Luo, Lin, Ohgaki, Hiroko, Wang, Bo, Wang, Xingchao, Wang, Zhenmin, Xu, Lei, Yang, Zhijun, Zhang, Jing, Zhao, Fu   +13 more
core   +1 more source