Results 101 to 110 of about 286,483 (372)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
PedWiz: A web-based tool for pedigree informatics
Frontiers in Genetics, 2013 A novel web-based tool PedWiz that pipelines the informatics process for pedigree data is introduced. PedWiz is designed to assist researchers in the analysis of pedigree data.
Yeunjoo E. Song, Robert C Elston
doaj +1 more source
ANALYSIS OF PEDIGREE LONG-LIVING PEDIGREES
, 2022 The study was conducted in 2022 and examines the hereditary predisposition to longevity by analyzing the pedigrees of 300 long-lived people who lived throughout their lives in the Carpathians (Ivano-Frankivsk region, Ukraine). The clinical and genealogical method is carried out in two stages.
Kozovyi, V. +3 more
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A case of arrhythmic cardiomyopathy caused by rare multiple gene mutations
Frontiers in Cardiovascular MedicineArrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterized by a high risk of ventricular tachycardia and sudden cardiac death, often involving the right ventricle or both ventricles, with the initial onset usually in adolescence or ...
Kaiqin Liang +7 more
doaj +1 more source
Anatomic brain asymmetry in vervet monkeys. [PDF]
, 2011 Asymmetry is a prominent feature of human brains with important functional consequences. Many asymmetric traits show population bias, but little is known about the genetic and environmental sources contributing to inter-individual variance.
Abaryan, Zvart +9 more
core +1 more source
Genetics, 2015 Research on the genetics of natural populations was revolutionized in the 1990s by methods for genotyping noninvasively collected samples. However, these methods have remained largely unchanged for the past 20 years and lag far behind the genomics era ...
Noah Snyder-Mackler +11 more
semanticscholar +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
The challenges of pedigree dog health: approaches to combating inherited disease
Canine Genetics and Epidemiology, 2015 The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnostic DNA disease tests, the full extent and ...
L. Farrell +4 more
semanticscholar +1 more source