Results 71 to 80 of about 223,945 (287)

Inbreeding depression in red deer calves [PDF]

, 2016
BACKGROUND Understanding the fitness consequences of inbreeding is of major importance for evolutionary and conservation biology. However, there are few studies using pedigree-based estimates of inbreeding or investigating the influence of environment ...
Clutton-Brock, Tim H, Kruuk, Loeske EB, Morris, Alison, Nussey, Daniel H, Pemberton, Josephine M, Walling, Craig A   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Association between family history, mutation locations, and prevalence of BRCA1 or 2 mutations in ovarian cancer patients

Cancer Medicine, 2019
We investigated the prevalence of germline BRCA mutations in a population‐based cohort of Austrian women diagnosed with ovarian cancer and its association with family history of cancer.
Christian F. Singer, Yen Y. Tan, Daniela Muhr, Christine Rappaport, Daphne Gschwantler‐Kaulich, Christoph Grimm, Stephan Polterauer, Georg Pfeiler, Andreas Berger, Muy‐Kheng M. Tea   +9 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Supporting long‐term sustainability of ex situ collections using a pedigree‐based population management approach

Applications in Plant Sciences, 2022
Premise Living collections maintained for generations are at risk of diversity loss, inbreeding, and adaptation to cultivation. To address these concerns, the zoo community uses pedigrees to track individuals and implement crosses that maximize founder ...
Jeremy A. Foster, Seana K. Walsh, Kayri Havens, Andrea T. Kramer, Jeremie B. Fant   +4 more
doaj   +1 more source

Identification and Characterization of Two Novel Compounds: Heterozygous Variants of Lipoprotein Lipase in Two Pedigrees With Type I Hyperlipoproteinemia

Frontiers in Endocrinology, 2022
BackgroundType I hyperlipoproteinemia, characterized by severe hypertriglyceridemia, is caused mainly by loss-of-function mutation of the lipoprotein lipase (LPL) gene.
Shuping Wang, Shuping Wang, Shuping Wang, Yiping Cheng, Yiping Cheng, Yingzhou Shi, Yingzhou Shi, Wanyi Zhao, Wanyi Zhao, Ling Gao, Ling Gao, Ling Gao, Ling Gao, Li Fang, Li Fang, Xiaolong Jin, Xiaolong Jin, Xiaoyan Han, Xiaoyan Han, Qiuying Sun, Qiuying Sun, Guimei Li, Jiajun Zhao, Jiajun Zhao, Chao Xu, Chao Xu   +25 more
doaj   +1 more source

A comparison of SNPs and microsatellites as linkage mapping markers: lessons from the zebra finch (Taeniopygia guttata) [PDF]

, 2010
Background: Genetic linkage maps are essential tools when searching for quantitative trait loci (QTL). To maximize genome coverage and provide an evenly spaced marker distribution a combination of different types of genetic marker are sometimes used.
Ball, A.D., Birkhead, T.R., Burke, T., Dawson, D.A., Slate, J., Stapley, J.   +5 more
core   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Pedigree Analysis of Warmblood Horses Participating in Competitions for Young Horses

Frontiers in Genetics, 2021
The aim of the study was to characterize the population structure and assess the genetic diversity of warmblood horses used in the show jumping discipline.
Tomasz Próchniak, Kornel Kasperek, Sebastian Knaga, Iwona Rozempolska-Rucińska, Justyna Batkowska, Kamil Drabik, Grzegorz Ziȩba   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source