Results 51 to 60 of about 116,425 (280)

Hereditary Gingival Fibromatosis: Report of Family Pedigree of Three Generations [PDF]

Journal of Clinical and Diagnostic Research, 2019
Gingival enlargement or gingival overgrowth can be defined as increase in the size of gingiva, caused due to a variety of etiological factors. One of the causes of gingival enlargement is hereditary gingival fibromatosis, which is a genetic disorder ...
JAIDEEP MAHENDRA, VIJAYALAKSHMI RAJARAM, SUJEETHA MUTHUKUMAR, SATHISH RAJENDRAN   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Pedigree error due to extra-pair reproduction substantially biases estimates of inbreeding depression [PDF]

, 2013
Understanding the evolutionary dynamics of inbreeding and inbreeding depression requires unbiased estimation of inbreeding depression across diverse mating systems.
Arcese, Peter, Nietlisbach, Pirmin, Reid, Jane M, Keller, Lukas F, Sardell, Rebecca J, Reid, Jane M., Marr, Amy B, Marr, Amy B., Keller, Lukas F., Sardell, Rebecca J.   +9 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Association between family history, mutation locations, and prevalence of BRCA1 or 2 mutations in ovarian cancer patients

Cancer Medicine, 2019
We investigated the prevalence of germline BRCA mutations in a population‐based cohort of Austrian women diagnosed with ovarian cancer and its association with family history of cancer.
Christian F. Singer, Yen Y. Tan, Daniela Muhr, Christine Rappaport, Daphne Gschwantler‐Kaulich, Christoph Grimm, Stephan Polterauer, Georg Pfeiler, Andreas Berger, Muy‐Kheng M. Tea   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

pedigree

, 2014
This is the reconstructed pedigree associated with all individuals in the phenotype ...
Géraldine Loot (3244239), David James Páez (3244242), Elise Mazé-Guilmo (3244236), Páez, David James, Lefèvre, Thierry, Mazé-Guilmo, Elise, Loot, Géraldine, Blanchet, Simon, Simon Blanchet (92497), Thierry Lefèvre (63585)   +9 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Supporting long‐term sustainability of ex situ collections using a pedigree‐based population management approach

Applications in Plant Sciences, 2022
Premise Living collections maintained for generations are at risk of diversity loss, inbreeding, and adaptation to cultivation. To address these concerns, the zoo community uses pedigrees to track individuals and implement crosses that maximize founder ...
Jeremy A. Foster, Seana K. Walsh, Kayri Havens, Andrea T. Kramer, Jeremie B. Fant   +4 more
doaj   +1 more source

Identification and Characterization of Two Novel Compounds: Heterozygous Variants of Lipoprotein Lipase in Two Pedigrees With Type I Hyperlipoproteinemia

Frontiers in Endocrinology, 2022
BackgroundType I hyperlipoproteinemia, characterized by severe hypertriglyceridemia, is caused mainly by loss-of-function mutation of the lipoprotein lipase (LPL) gene.
Shuping Wang, Shuping Wang, Shuping Wang, Yiping Cheng, Yiping Cheng, Yingzhou Shi, Yingzhou Shi, Wanyi Zhao, Wanyi Zhao, Ling Gao, Ling Gao, Ling Gao, Ling Gao, Li Fang, Li Fang, Xiaolong Jin, Xiaolong Jin, Xiaoyan Han, Xiaoyan Han, Qiuying Sun, Qiuying Sun, Guimei Li, Jiajun Zhao, Jiajun Zhao, Chao Xu, Chao Xu   +25 more
doaj   +1 more source