Results 211 to 220 of about 76,180 (261)

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

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Sampling Correction in Pedigree Analysis

Statistical Applications in Genetics and Molecular Biology, 2003
Usually, a pedigree is sampled and included in the sample that is analyzed after following a predefined non-random sampling design comprising several specific procedures. To obtain a pedigree analysis result free from the bias caused by the sampling procedures, a correction is applied to the pedigree likelihood.
Robert C. Elston, Ida Malkin
exaly   +3 more sources

Pedigree Analysis

Postgraduate Medicine, 1966
The basic reasons for the discrepancy between predicted and observed ratios or patterns of inheritance of genetic traits are related to penetrance and expressivity. Difficulties in collection and ascertainment of human data pose additional problems in pedigree analysis.
openaire   +3 more sources

Metropolis sampling in pedigree analysis

Statistical Methods in Medical Research, 1993
This paper reviews and develops the applications of Markov chain Monte Carlo methods in pedigree analysis, with particular stress on the Metropolis algorithm. In likelihood based genetic analyses, standard deterministic algorithms often fail because of the computational complexity of the observed pedigree data under a proposed genetic model.
E, Sobel, K, Lange
openaire   +2 more sources

Automation of yeast pedigree analysis

IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004, 2004
Yeast pedigree analysis-isolation and characterization of the products of mitotic cell divisions throughout the lifespan of an individual cell-is a manually intensive process that requires a biologist to manipulate single yeast cells every 90 minutes for as long as 150 hours.
John Koschwanez, Mark Holl, Michael McMurray, Daniel Gottschling, Deirdre R. Meldrum   +4 more
openaire   +2 more sources

Extensions to Pedigree Analysis

Human Heredity, 1975
A computer method for calculating recurrence under the polygenic threshold model is explained. This approach permits accurate risk evaluation for pedigrees of arbitrary structure and large enough ...
K. Lange, R.C. Elston
openaire   +1 more source

Pedigree analysis in families with febrile seizures

American Journal of Medical Genetics, 1996
Febrile seizures are the most common form of seizures, occurring in an estimated 2-5% of North American children. We carried out a systematic pedigree study of febrile seizure probands. Forty of 52 probands (77%) in a referral population selected for increased severity had more than one case per family: one family had 10 cases, one family had 7, 3 ...
W G, Johnson, S L, Kugler, E S, Stenroos, M C, Meulener, I, Rangwalla, T W, Johnson, D E, Mandelbaum   +6 more
openaire   +2 more sources

Combined Linkage and Association Analysis in Pedigrees

Genetic Epidemiology, 2001
We applied a combined linkage and association model for quantitative traits in pedigrees to identify possible functional polymorphisms and to test for association resulting from population stratification and admixture. Functional polymorphisms are identified as variants that are significantly associated with a trait (high x2 value) and showing no ...
K D, Siegmund, H, Vora, W J, Gauderman
openaire   +2 more sources