Results 81 to 90 of about 554,067 (294)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Characterization of peer support services for substance use disorders in 11 US emergency departments in 2020: findings from a NIDA clinical trials network site selection process

Addiction Science & Clinical Practice
Introduction Emergency departments (ED) are incorporating Peer Support Specialists (PSSs) to help with patient care for substance use disorders (SUDs).
Lindsey K Jennings, Laura Lander, Tricia Lawdahl, Erin A. McClure, Angela Moreland, Jenna L. McCauley, Louise Haynes, Timothy Matheson, Richard Jones, Thomas E. Robey, Sarah Kawasaki, Phillip Moschella, Amer Raheemullah, Suzette Miller, Gina Gregovich, Deborah Waltman, Kathleen T. Brady, Kelly S. Barth   +17 more
doaj   +1 more source

Gateway to College: Lessons from Implementing a Rigorous Academic Program for At-Risk Young People [PDF]

, 2015
Despite efforts to improve the high school graduation rate in the United States, an estimated 7,200 students drop out of high school every day -- a staggering 1.3 million every year.
Brian Bayes, Jacklyn Altuna Willard, John Martinez   +2 more
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Systematizing peer recovery support services for substance use disorder: a taxonomy for measuring recovery milestones

Frontiers in Public Health
BackgroundRecovery from substance use disorder (SUD) is a complex and individualized process requiring multifaceted support systems. Peer recovery support services (PRSS), provided by Peer Workers, bridge the gap between formal intervention and personal ...
Kimberly Horn, Ryan E. Flinn, Angela Marie Hagaman, Kristyn Zajac, Lauren A. Hoffman, Melissa N. Poulsen, Camille C. Cioffi, Ducel Jean-Berluche, Ethan Spana, Patrick F. Hibbard, Tess K. Drazdowski, Aaron Hogue   +11 more
doaj   +1 more source

The Influence of Professional Investors on the Failure of Management Buyout Attempts [PDF]

, 1996
In a sample of 111 MBO offers between 1984 and 1987, almost 30% attract new blockholders. These blockholders are primarily professional investors who act to facilitate a takeover by a higher bidder, thus increasing returns to both themselves and other ...
Peck, Sarah
core   +1 more source

ACCCN Workforce Standards for Intensive Care Nursing: Systematic and evidence review, development, and appraisal [PDF]

, 2017
Background: The intensive care nursing workforce plays an essential role in the achievement of positive healthcare outcomes. A growing body of evidence indicates that inadequate nurse staffing and poor skill mix are associated with negative outcomes for ...
Chamberlain, Diane, Fulbrook, Paul, Pollock, Wendy   +2 more
core   +3 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Specialists’ learning from facilitating group peer telementoring: a qualitative study

BMC Medical Education
Background Group peer telementoring supports interprofessional learning through multi-directional and synchronous engagement where experienced and knowledgeable individuals exchange guidance and support with differently experienced and knowledgeable ...
R. Sam Larson, James W. Dearing, Nagesh Rao, Caryn E. Medved   +3 more
doaj   +1 more source