Results 91 to 100 of about 2,859,402 (254)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Commentary: High Intensity Physical Rehabilitation Later Than 24 h Post Stroke Is Beneficial in Patients: A Pilot Randomized Controlled Trial (RCT) Study in Mild to Moderate Ischemic Stroke

Frontiers in Neurology, 2020
Mari Nakao, Mari Nakao, Mari Nakao, Masahiro Banno, Masahiro Banno, Masahiro Banno, Yuki Kataoka, Yuki Kataoka, Yuki Kataoka, Yuki Kataoka, Shunsuke Taito, Shunsuke Taito   +11 more
doaj   +1 more source

Making available scientific information in the third millennium: perspectives for the neuroscientific community [PDF]

, 2006
The rules governing the globalised process of sharing scientific information in the research community are rapidly changing. From the 1950s, commercial publishers started owning a large number of scientific journals and consequently the marketable value ...
Alleva, Enrico, Branchi, Igor
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

To be SEER 1.0 or not to be SEER 2.0? That is one of a few questions

Online Brazilian Journal of Nursing, 2007
The intent of this editorial is to share the fears related to the migration to a new version of the OJS/PKP and to highlight the strengths of the OBJN with the use of the OJS.
Isabel CF da Cruz
doaj  

Research Ethics Committees (RECs) and the Creaking Piers of Peer Review [PDF]

[No abstract][No keywords]
John Holmwood
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Using Cinéma Vérité (Truthful Cinema) to Facilitate Replication and Accountability in Psychological Research

Frontiers in Psychology, 2013
To increase replication and accountability, it is proposed that researchers make audio/video recordings of laboratory protocols using currently available technologies, such as smart-phones.
Jerry eSuls
doaj   +1 more source

An integrative approach to online conference review management : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Information System in Massey University [PDF]

, 2003
Academic conferences play an important role in modern science and technology development. They provide venues for people involved in particular research areas to communicate with each other, share research achievement, and understand the current leading ...
Meng, He
core