Results 101 to 110 of about 2,725,232 (305)
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau+11 more
wiley +1 more source
What does Hirsch index evolution explain us? A case study: Turkish Journal of Chemistry
The evolution of Turkish Journal of Chemistry (Turk J. Chem) Hirsch index (h-index) over the period 1995-2005 is studied and determined in the case of the self and without self-citations. It is seen that the effect of Hirsch index of Turk J.
Karamustafaoglu, Orhan+2 more
core
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti+10 more
wiley +1 more source
Peer review processes risk stifling creativity and limiting opportunities for game-changing scientific discoveries [PDF]
Today, academics must prepare written proposals describing the research they wish to conduct and submit them to funding agencies for evaluation – a process known as peer review.
Braben, Don, Dowler, Rod
core
Research on peer review and biomedical publication [PDF]
Sara Schroter+2 more
openaire +2 more sources
Research papers, gender bias and peer-review [PDF]
Following our 2017 Editorial Board meeting in April and with the first half of 2017 now passed, I am delighted to provide our readers with an update on how Biology Letters is progressing. At the time of writing, we have so far this year published 92 papers and completed two Special Features ...
openaire +3 more sources
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit+19 more
wiley +1 more source
To increase replication and accountability, it is proposed that researchers make audio/video recordings of laboratory protocols using currently available technologies, such as smart-phones.
Jerry eSuls
doaj +1 more source
Peer-review of the research flow
An increasing number of researchers use ICT tools for the production and processing of research outcomes. In the last decade, research infrastructures (organizational and technological facilities supporting research activities) are investing in "e-infrastructures" that leverage ICT tools, services, guidelines and policies to support the digital ...
Bardi A, Casarosa V, Manghi P
openaire +2 more sources
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani+14 more
wiley +1 more source