Results 101 to 110 of about 2,725,232 (305)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

What does Hirsch index evolution explain us? A case study: Turkish Journal of Chemistry

open access: yes, 2007
The evolution of Turkish Journal of Chemistry (Turk J. Chem) Hirsch index (h-index) over the period 1995-2005 is studied and determined in the case of the self and without self-citations. It is seen that the effect of Hirsch index of Turk J.
Karamustafaoglu, Orhan   +2 more
core  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Peer review processes risk stifling creativity and limiting opportunities for game-changing scientific discoveries [PDF]

open access: yes, 2017
Today, academics must prepare written proposals describing the research they wish to conduct and submit them to funding agencies for evaluation – a process known as peer review.
Braben, Don, Dowler, Rod
core  

Research papers, gender bias and peer-review [PDF]

open access: yesBiology Letters, 2017
Following our 2017 Editorial Board meeting in April and with the first half of 2017 now passed, I am delighted to provide our readers with an update on how Biology Letters is progressing. At the time of writing, we have so far this year published 92 papers and completed two Special Features ...
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Using Cinéma Vérité (Truthful Cinema) to Facilitate Replication and Accountability in Psychological Research

open access: yesFrontiers in Psychology, 2013
To increase replication and accountability, it is proposed that researchers make audio/video recordings of laboratory protocols using currently available technologies, such as smart-phones.
Jerry eSuls
doaj   +1 more source

Peer-review of the research flow

open access: yes, 2017
An increasing number of researchers use ICT tools for the production and processing of research outcomes. In the last decade, research infrastructures (organizational and technological facilities supporting research activities) are investing in "e-infrastructures" that leverage ICT tools, services, guidelines and policies to support the digital ...
Bardi A, Casarosa V, Manghi P
openaire   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

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