Results 41 to 50 of about 994,354 (266)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Philippine Journal of Otolaryngology Head and Neck Surgery, 2014 Peer review is widely accepted as the hallmark of scholarly, scientific publication. It helps journal editors determine whether research conclusions are justified and “new,” gives them an idea of the potential or actual significance of a work1 and adds a
José Florencio F. Lapeña
doaj +1 more source
arXiv, 2012 In computer science, conferences and journals conduct peer review in order to decide what to publish. Many have pointed out the inherent weaknesses in peer review, including those of bias, quality, and accountability. Many have suggested and adopted refinements of peer review, for instance, double blind peer review with author rebuttals.
arxiv
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Chinese Medicine in the Management of New and Emerging Infectious Diseases
Digital Chinese Medicine, 2018 : Emerging infectious diseases are an important problem in medicine, and many continue to pose a global threat. However, the management of new and emerging infections is usually difficult due to a lack of knowledge and tools to address the problem.
Viroj Wiwanitkit
doaj
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Auctions and Peer Prediction for Academic Peer Review [PDF]
arXiv, 2021 Peer reviewed publications are considered the gold standard in certifying and disseminating ideas that a research community considers valuable. However, we identify two major drawbacks of the current system: (1) the overwhelming demand for reviewers due to a large volume of submissions, and (2) the lack of incentives for reviewers to participate and ...
arxiv
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
Peer Review and the PJOHNS: Principles, Problems, and Promise
Philippine Journal of Otolaryngology Head and Neck Surgery, 2018 The Philippine Journal of Otolaryngology Head and Neck Surgery (PJOHNS) is the official refereed journal of the Philippine Society of Otolaryngology Head and Neck Surgery (PSOHNS).
José Florencio F. Lapeña
doaj +1 more source