Results 81 to 90 of about 994,354 (266)

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

Increasing the degree of acceptability for chatbots in technical support systems for educational sector by using ML and semantic web

open access: yesAlexandria Engineering Journal
Work on digital transformation is one of the main features of the fourth economic revolution, which tends to benefit from technology in various aspects of life.
Adel A. Bahaddad
doaj  

Past Performance as Predictor of Successful Grant Applications: A Case Study [PDF]

open access: yesarXiv, 2009
Competitive allocation of research funding is a major mechanism within the science system. It is fundamentally based on the idea of peer review. Peer review is central in project selection as peers are considered to be in a unique position to identify and select the best and most innovative researchers and research projects.
arxiv  

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

open access: yesMolecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa   +13 more
wiley   +1 more source

Inter-rater reliability and convergent validity of F1000Prime peer review [PDF]

open access: yesarXiv, 2014
Peer review is the backbone of modern science. F1000Prime is a post-publication peer review system of the biomedical literature (papers from medical and biological journals). This study is concerned with the inter-rater reliability and convergent validity of the peer recommendations formulated in the F1000Prime peer review system. The study is based on
arxiv  

Review of Peer Evaluation Research [PDF]

open access: green, 1978
Ronald G. Downey, Paul J. Duffy
openalex   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

Long Dan Xie Gan Formula Granule Promotes Pro-Inflammatory Cytokine Expression in Female Guinea Pigs with Recurrent Genital Herpes

open access: yesDigital Chinese Medicine, 2018
: Objective To explore the effects of Long Dan Xie Gan formula granule (LDXGFG) on regulation of pro-inflammatory cytokines in female guinea pigs with recurrent genital herpes (herpes simplex virus 2, HSV-2).Methods Levels of pro-inflammatory cytokines ...
Lin KUANG   +4 more
doaj  

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