Results 181 to 190 of about 951,196 (306)

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

Advanced Science, EarlyView.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu, Yihan Wang, Haiyun Chen, Xinye Yu, Tingyu Wang, Yajing Weng, Meihong Guo, Ying Huang, Gaojian Tao, Wangsen Cao, Yong Wang, Daojuan Wang   +11 more
wiley   +1 more source

Utilizing near-peer teaching to expand obesity medicine training within an internal medicine residency curriculum. [PDF]

J Clin Transl Endocrinol
Forrest A, Negron Marte MG, George A, Liu L, Mayer SB.   +4 more
europepmc   +1 more source

A concept for adapting medical education to the next generations via three-staged digital peer teaching key feature cases. [PDF]

Wien Med Wochenschr, 2023
Supper P, Urban D, Acker I, Linke FS, Kienast P, Praschinger A, Anvari-Pirsch A.   +6 more
europepmc   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

The Use of Peer Teaching in the Online Clinical PBL: The Medical Students' Perspectives [Letter]. [PDF]

Adv Med Educ Pract
Dahir M, Berry LC, Khan SS.
europepmc   +1 more source

The Effect of Peer Teaching on the Quality of Report Writing Based on the Nursing Process. [PDF]

Iran J Nurs Midwifery Res, 2022
Khodadadi A, Froutan R, Salehian M, Mazlom SR.   +3 more
europepmc   +1 more source

Clickable Microgel Inks Enable Spatioselective, Multi‐Stimuli Programmable Assembly of Materials

Advanced Science, EarlyView.
Clickable microgel inks enable direct ink writing of hydrogel architectures with intrinsic spatioselective and programmable multi‐responsiveness. By combining pH‐responsive and temperature‐responsive microgel building blocks through Diels‐Alder interparticle crosslinking, the assemblies exhibit controllable swelling and shape changes.
Junho Moon, Frank Gardea, Madeline A. Morales, Svetlana Sukhishvili   +3 more
wiley   +1 more source

The Use of Peer Teaching in the Online Clinical PBL: The Medical Students' Perspectives [Response to Letter]. [PDF]

Adv Med Educ Pract
Romão GS, Rocha SR, Faria Junior M, Durand MT, Bestetti RB.   +4 more
europepmc   +1 more source

The development, implementation, and evaluation of a medical student peer teaching training curriculum during a high-fidelity prehospital trauma simulation. [PDF]

AEM Educ Train, 2022
Rudinsky SL, Spalding C, Conley SP, Everett L, Cole R.   +4 more
europepmc   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source