Results 161 to 170 of about 87,709,212 (242)

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

Peer-Support Interventions for Self-Management in Adults Living with an Intestinal Ostomy: A Scoping Review. [PDF]

Nurs Rep
Teixeira CSM, Castilho AFOM, Marques AA.
europepmc   +1 more source

Architected Spatially Deterministic Multiscale Phase Segregation in Block Copolymer Composites for Augmented Radiative Cooling

Advanced Science, EarlyView.
Multiscale phase segregation in block copolymers enables spatially deterministic structuring from molecular to macroscopic scales, decoupling solar scattering and infrared emission for augmented radiative cooling. ABSTRACT Passive radiative cooling, which reflects solar irradiation while emitting heat through the atmospheric window, provides a ...
Mingxin Feng, Feiyang Zhou, Haoran Cai, Wenchao Zhai, Shuangjiang Feng, Yanmei Liu, Xiaohai Bu, Man He, Dudong Feng, Shuang Liang, Yuming Zhou   +10 more
wiley   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Quantifying the Dynamics of Network Detachment Across Scientific, Technological, Commercial, and Pharmacological Domains

Advanced Science, EarlyView.
Across scientific, technological, commercial, and pharmacological domains, individuals and organizations disengage from a previously adopted practice not at random, but as their network neighbors detach. The probability of detachment rises with the number of neighbors who have already disengaged. Preferential detachment reshapes network disintegration,
Binglu Wang, Ching Jin, Chaoming Song, Johannes Bjelland, Brian Uzzi, Dashun Wang   +5 more
wiley   +1 more source

Synergistic Mechano‐Fluidic Self‐Fusion of Poly(Vinyl Alcohol)‐Modified Liquid‐Metal Particles for Post‐Treatment‐Free Soft Electronics

Advanced Science, EarlyView.
Poly(vinyl alcohol)‐modified liquid‐metal particles form conductive networks through spray‐induced self‐fusion without additional post‐treatment. Spray impact initiates oxide‐shell rupture and electrical contact, while subsequent Marangoni flow and capillary forces promote particle redistribution, neck growth, and network consolidation. This sequential
Keun‐Young Yook, Sangwon Kim, Chansoo Kim, Minkyong Kang, Yurim Lee, Mido Kim, Kijun Park, Seung Yeop Han, Seung‐Woo Cho, Gun‐Hee Lee, Kayoung Son, Hanbit Jang, Tae Young Kim, Jungmok Seo   +13 more
wiley   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source