Results 51 to 60 of about 82,921 (179)
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan +8 more
wiley +1 more source
Thrombin generation by asparaginase [PDF]
, 2012 Das bakterielle Enzym Asparaginase ist ein sehr effektives Zytostatikum in der Therapie lymphoproliferativer Erkrankungen. Die Eigenschaft des Enzyms, die plasmatische Blutgerinnung zu verändern, ist eine bekannte klinische Komplikation.
Chalkitis, Danuta
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British Journal of Clinical Pharmacology, EarlyView.Background By age three, 5%–75% of children have a documented antibiotic allergy (AL). Despite this prevalence, recognition remains low because of limited clinician knowledge and time. Our study evaluates a novel approach to identifying AL using electronic medical record (EMR) prescription patterns.
Georgia Koutsaplis +5 more
wiley +1 more source
Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia
Interdisciplinary Medicine, EarlyView.For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang +13 more
wiley +1 more source
, 2011 2011-03PEG is useful substance among any conservation materials, but it will be contaminants made of dead carbon for radiocarbon dating. Removal of PEG must be attempted to the conserved woods before radiocarbon dating.
西本, 寛 +5 more
core +1 more source
VIEW, EarlyView.Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf +5 more
wiley +1 more source
Erwinia chrysanthemi desensitisation in a patient with recurrent B-cell acute lymphoblastic leukemia
Alergologia PolskaMany hypersensitivity reactions (HSRs) are associated with chemotherapeutic agents, particularly platinum compounds, taxanes, epipodophyllotoxins, procarbazine, and L-asparaginase. For reactions to native Escherichia coli (E.
Seda Çevik +5 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud +14 more
wiley +1 more source
, 2011 Asparaginase is one of the main drugs used to treat acute lymphoblastic leukemia and certain non-Hodgkin lymphomas. The drug is a bacterial product, and this results in differences in activity, efficacy, and side effects among the various marketed ...
van den Berg, Henk, Henk van den Berg
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