Results 71 to 80 of about 82,921 (179)

Acute pancreatitis following asparaginase treatment in pediatric acute lymphoblastic leukemia with a heterozygous SPINK1 c.194 + 2T>C intronic variant: a case report

Frontiers in Pediatrics
BackgroundAsparaginase is a critical component of chemotherapy for pediatric acute lymphoblastic leukemia (ALL), but its use is often complicated by asparaginase-associated pancreatitis (AAP). Genetic predispositions, such as variants in the SPINK1 gene,
Hua Zhou, Jun Lu, Tao Wang, Tao Wang, Xiaoyan Gu, Xueya Li, Jing Zhao   +6 more
doaj   +1 more source

PEG-L-CHOP treatment is safe and effective in adult extranodal NK/T-cell lymphoma with a low rate of clinical hypersensitivity

BMC Cancer, 2018
Background The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL).
Wen Zheng, Yuhuan Gao, Xiaoyan Ke, Weijing Zhang, Liping Su, Hanyun Ren, Ningjing Lin, Yan Xie, Meifeng Tu, Weiping Liu, Lingyan Ping, Zhitao Ying, Chen Zhang, Lijuan Deng, Xiaopei Wang, Yuqin Song, Jun Zhu   +16 more
doaj   +1 more source

Superior sagittal sinus thrombosis in the course of mixed phenotype acute leukaemia treated with acute lymphoblastic leukaemia-like therapy—a case report

Thrombosis Journal, 2023
Mixed phenotype acute leukaemia (MPAL) is associated with worse overall survival, compared with other acute leukaemias in adults. Lack of clear treatment guidelines makes the therapy challenging. ALL-like induction and consolidation treatment followed by
Wojciech Lizurej, Łukasz Mazurkiewicz, Michał Kowalski, Sylwia Szydłowska, Michał Wyrzykowski, Krzysztof Lewandowski   +5 more
doaj   +1 more source

Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers, Chantal Éthier, Caroline Laverdière, Nathalie Alos, Thai Hoa Tran, Marie‐Claude Pelland‐Marcotte   +5 more
wiley   +1 more source

PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma. [PDF]

Chin J Cancer Res, 2017
Objective:Although L-asparaginase (L-ASP) is a standard treatment for lymphoblastic lymphoma (LBL),hypersensitivity reactions by some patents limit its application.Polyethylene glycol-conjugated asparaginase (PEGASP) has a lower immunogenicity and is a ...
Zheng W, Ren H, Ke X, Xue M, Zhang Y, Xie Y, Lin N, Tu M, Liu W, Ping L, Ying Z, Zhang C, Deng L, Wang X, Song Y, Zhu J.   +15 more
europepmc   +2 more sources

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

Intravenous pegylated asparaginase versus intramuscular native Escherichia coli L-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial [PDF]

, 2015
l-asparaginase is a universal component of treatment for childhood acute lymphoblastic leukaemia, and is usually administered intramuscularly. Pegylated Escherichia coli asparaginase (PEG-asparaginase) has a longer half-life and is potentially less ...
Vrooman, Lynda M, Stevenson, Kristen E, Silverman, Lewis B, Asselin, Barbara L, Place, Andrew E, Sallan, Stephen E, Laverdiere, Caroline, Blonquist, Traci M, O'Brien, Jane E, Clavell, Luis A, Neuberg, Donna S, Kelly, Kara M, Harris, Marian H, Welch, Jennifer J G, Cole, Peter D, Supko, Jeffrey G, Kutok, Jeffery L, Athale, Uma H, Schorin, Marshall A, Leclerc, Jean-Marie, Michon, Bruno, Hunt, Sarah K, Lipshultz, Steven E   +22 more
core   +1 more source

Minimally-Myelosuppressive Asparaginase-Containing Induction Regimen for Treatment of a Jehovah’s Witness with mutant IDH1/NPM1/NRAS Acute Myeloid Leukemia

Pharmaceuticals, 2016
Treatment of patients with acute myeloid leukemia (AML) who do not wish to accept blood product transfusion, including Jehovah’s Witnesses, is extremely challenging. The use of conventional chemotherapy for induction of complete remission (CR) results in
Ashkan Emadi, Najeebah A. Bade, Brandi Stevenson, Zeba Singh   +3 more
doaj   +1 more source

Hidden Behind Ascites: An Atypical Pediatric Presentation of T‐Cell Acute Lymphoblastic Leukemia—A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT This case describes a child with T‐cell acute lymphoblastic leukemia (T‐ALL) presenting atypically with ascites and bilateral pedal edema, initially suggesting autoimmune hepatitis. The diagnosis was established only after flow cytometry of ascitic fluid.
Kainat Shaikh, Zahra Anas, Samia Rajput, Alizeh Zaib, Ayesha Saleem, Md Ariful Haque   +5 more
wiley   +1 more source

Challenges in overcoming advanced-stage or relapsed refractory extranodal NK/T-cell lymphoma: meta-analysis of individual patient data

Frontiers in Oncology
IntroductionExtranodal NK/T-cell lymphoma (ENKTCL), a non-Hodgkin lymphoma, is known for its destructive local impact on nasal structures and systemic induction of inflammatory cytokines.
Tong Yoon Kim, Tong Yoon Kim, Tae Jung Kim, Eun Ji Han, Gi June Min, Gi June Min, Youngwoo Jeon, Youngwoo Jeon, Seok-Goo Cho, Seok-Goo Cho   +9 more
doaj   +1 more source