Results 91 to 100 of about 82,921 (179)

Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: Premedication and desensitization may not be sufficient [PDF]

, 2013
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene glycol conjugated asparaginase (PEG-ASP) is preferred. Anaphylaxis with PEG-ASP is rare.
Buyuktiryaki, Betul, ŞAHİNER, ÜMİT MURAT, Aytac, ŞEVKİYE SELİN, Tuncer, Murat, Altan, Ilhan, Gokce, Muge, YAVUZ, SİNAN, Sackesen, Cansin, Tuncer, Ayfer, AYTAÇ EYÜPOĞLU, ŞEVKİYE SELİN   +9 more
core   +1 more source

Production of extracellular l-asparaginase: from bioprospecting to the engineering of an antileukemic biopharmaceutical [PDF]

, 2014
L-asparaginase is an enzyme clinically accepted as an anti-tumor agent for the treatment of acute lymphoblastic leukemia and lymphosarcoma.
Oliveira, M. A., Mazzola, P. G., Monteiro, G., Farsky, S. H. P., Sette, L. D., Pessoa, A., Rangel Yagui, C. O., Carvalho, J. C. M., Magalhães, P. O., Farías, J. G. A., Motta, C. M. S., CONVERTI, ATTILIO   +11 more
core  

Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity

Acta Pharmaceutica Sinica B
One of the leading therapies for acute lymphoblastic leukemia (ALL) is the chemotherapeutic agent PEGylated E. coli-derived-l-asparaginase (PEG-ASNase).
Yin Zhu, Yuyin Wang, Keito Hoshitsuki, Da Yang, Lauren Kokai, Xiaochao Ma, Wen Xie, Christian A. Fernandez   +7 more
doaj   +1 more source

Asparaginase-related venous thrombosis in UKALL 2003- re-exposure to asparaginase is feasible and safe. [PDF]

, 2010
We report the incidence and outcome of venous thrombosis (VT) in the UK acute lymphoblastic leukaemia (ALL) 2003 trial. VT occurred in 59/1824 (3.2%) patients recruited over 5 years with 90% occurring during a period of Asparagine depletion.
Vora, A, Mitchell, C, Richards, Susan, Qureshi, A, Goulden, N, Richards, S   +5 more
core   +1 more source

Enzymatic depletion of circulating glutamine is immunosuppressive in cancers

iScience
Summary: Although glutamine addiction in cancer cells is extensively reported, there is controversy on the impact of glutamine metabolism on the immune cells within the tumor microenvironment (TME).
Monish Kumar, Ankita Leekha, Suman Nandy, Rohan Kulkarni, Melisa Martinez-Paniagua, K. M. Samiur Rahman Sefat, Richard C. Willson, Navin Varadarajan   +7 more
doaj   +1 more source

Bell Ringers at Pacific University Wassail party [PDF]

, 1960
Pacific University Bell Ringers at the Wassail party in the 1960's[Back] Photo By Peg ...
Peg Oslund, photographer
core  

A Single Dose of PEG-Asparaginase at the Beginning of Induction Not Only Accelerates MRD Clearance but Also Improves Long-Term Outcome in Children with B-Lineage ALL. [PDF]

Cancers (Basel), 2023
Popov A, Henze G, Roumiantseva J, Bydanov O, Belevtsev M, Verzhbitskaya T, Movchan L, Tsaur G, Lagoyko S, Zharikova L, Myakova N, Litvinov D, Khlebnikova O, Streneva O, Stolyarova E, Ponomareva N, Novichkova G, Fechina L, Aleinikova O, Karachunskiy A.   +19 more
europepmc   +1 more source

GENETIC POLYMORPHISMS RELATED TO PEG-ASPARAGINASE HYPERSENSITIVITY IN THE BRAZILIAN PEDIATRIC POPULATION

Hematology, Transfusion and Cell Therapy
Introduction/Objective: PEG-Asparaginase (PEG-ASNase) is critical in treating pediatric acute lymphoblastic leukemia (ALL). However, hypersensitivity reactions and inactivations associated with ASNase are major patient challenges. The detection of single nucleotide polymorphisms (SNPs), which recognize, in advance, patients who will develop ...
DK Cecconello, KAS Silva, ECM Senna, MM Lins, IMQS Magalhães, AVL Sousa, C Rechenmacher, LE Daudt, MB Michalowski   +8 more
openaire   +2 more sources

Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients [PDF]

, 2012
Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts.
Rytting ME
core  

Research progress on the PEGylation of therapeutic proteins and peptides (TPPs)

Frontiers in Pharmacology
With the rapid advancement of genetic and protein engineering, proteins and peptides have emerged as promising drug molecules for therapeutic applications.
Chunxiao Li, Chunxiao Li, Ting Li, Xinya Tian, Xinya Tian, Wei An, Wei An, Zhenlong Wang, Zhenlong Wang, Bing Han, Bing Han, Hui Tao, Hui Tao, Jinquan Wang, Jinquan Wang, Xiumin Wang, Xiumin Wang   +16 more
doaj   +1 more source