Results 81 to 90 of about 82,921 (179)

Delivering Proteins and Enzymes to Solid Tumors Through the Development of Stimuli‐Responsive Nanocarriers

ChemNanoMat, Volume 12, Issue 6, June 2026.
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo, Diana Benita‐Donadios, Sandra Jiménez‐Falcao, Alejandro Baeza   +3 more
wiley   +1 more source

PANCREATITE AGUDA GRAVE COMO COMPLICAÇÃO APÓS USO DE PEG-ASPARAGINASE NO TRATAMENTO DA LLA-B

Hematology, Transfusion and Cell Therapy
Objetivos: Relatar um caso de pancreatite aguda grave secundária ao uso de PEG-Asparaginase no tratamento da Leucemia Linfoblástica Aguda de células-B. Materiais e métodos: Relato de Caso. Resultados: Paciente de 15 anos, sexo masculino, diagnosticado em
MMS Silva, LP Almeida, MJA Sousa, ML Silva, IG Ramos, RE Emídio, FL Nogueira, JL Vendramini, NAHL Silva   +8 more
doaj   +1 more source

L-asparaginase treatment in acute lymphoblastic leukemia [PDF]

, 2010
Asparaginases are a cornerstone of treatment protocols for acute lymphoblastic leukemia (ALL) and are used for remission induction and intensification treatment in all pediatric regimens and in the majority of adult treatment protocols.
Martin Schrappe, Carmelo Rizzari, Hunger, S.P. (Stephen), Schrappe, M. (Martin), Silverman, LB, Pui, C-H, Pui, C.H. (Ching-Hon), Silverman, L.B. (Lewis), Nicola Goekbuget, Rizzari, C. (Carmelo), Hunger, SP, Rizarri, C, Schrappe, M, Boos, J. (Joachim), Ching-Hon Pui, Pieters, Rob, Baruchel, A, Stephen P. Hunger, Boos, J, Goekbuget, N, Rob Pieters, Joachim Boos, Lewis Silverman, Andre Baruchel, Goekbuget, N. (Nicola), Baruchel, A. (André), Pieters, R. (Rob)   +26 more
core   +1 more source

Durable MRD‐Negative Remission With Blinatumomab and Venetoclax in Heavily Pretreated Relapsed/Refractory Philadelphia Chromosome‐Positive Acute Lymphoblastic Leukemia

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Introduction Tyrosine kinase inhibitors (TKIs) are standard therapy for Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL); however, relapsed or refractory disease remains challenging due to resistance driven by ABL kinase domain mutations.
Mohammad Shahzaib Qadir, Shereen Farooq, Omer Jamy   +2 more
wiley   +1 more source

Peg Nelson [PDF]

, 2010
Date:1913-09Margaret ?Peg' Nelson was the daughter of Lewis Bloomfield and Lillian Myrtle Kunoth, a well known Central Australian pastoral family. Peg and her sister Jean grew up at Loves Creek Station.
Nelson, Margaret Caroline
core  

Cerebrovascular thrombosis during pediatric ALL therapy: a case series highlighting temporal association with PEG-asparaginase exposure

Frontiers in Pediatrics
BackgroundCerebrovascular thrombosis is an uncommon but potentially life-threatening complication of chemotherapy in children with acute lymphoblastic leukemia (ALL).
Chen Xu, Jianchun Lu, Weihao Ling, Bingbing Zhang, Huan Xu, Jihong Tang   +5 more
doaj   +1 more source

Clinical And Demographic Factors Associated With Peg-Asparaginase-Related Toxicities In Patients With Acute Lymphoblastic Leukemia [PDF]

, 2019
Introduction: Polyethylene glycol (PEG)-asparaginase is one of the first-line drugs in pediatric ALL treatment. Although a complete and prolonged treatment with PEGasparaginase has been instrumental in improving the survival of ALL patients, it is ...
Dharia, Priyadarshani
core   +1 more source

Erroneous exchange of asparaginase forms in the treatment of acute lymphoblastic leukemia [PDF]

, 2011
Item does not contain fulltextFor the treatment of children with acute lymphoblastic leukemia (ALL), Dutch pediatric oncologists use the Dutch Childhood Oncology Group ALL 10 protocol.
Bemt, P.M. van den, Cheung, Ka-Chun, Torringa, Maarten L. J., de Smet, PAGM, Pieters, R., Maarten L.J. Torringa, Bemt, Patricia, Tamminga, RYJ, van den Bemt, Patricia M. L. A., van den Bemt, Patricia M. L. A.; id_orcid, Ka-Chun Cheung, Torringa, M.L., Pieters, Rob, Cheung, KC, Rienk Y.J. Tamminga, Peter A.G.M. de Smet, Cheung, K.C., Rob Pieters, Tamminga, R.Y., Tamminga, Rienk Y. J., Smet, P.A. de, Torringa, MLJ, de Smet, Peter A. G. M., Patricia M.L.A. van den Bemt   +23 more
core   +1 more source

Pegademase bovine (PEG-ADA) for the treatment of infants and children with severe combined immunodeficiency (SCID) [PDF]

, 2009
Adenosine deaminase deficiency (ADA) is a rare, inherited disorder of purine metabolism characterized by immunodeficiency, failure to thrive and metabolic abnormalities. A lack of the enzyme ADA allows accumulation of toxic metabolites causing defects of
Claire Booth, Booth, C, H Bobby Gaspar, Gaspar, HB   +3 more
core  

Osteonecrosis was associated with higher plasma dexamethasone and asparaginase levels in mice receiving both dexamethasone and asparaginase treatment. [PDF]

, 2016
BALB/cJ males received dexamethasone (4 mg/L) and PEG-asparaginase (1200 IU/kg i.p. twice weekly) for 6 weeks. Blood samples were collected at the end of week 6 (approximately 3.5 days after last asparaginase injection).
Xiangjun Cai (780959), Leonard A. Mattano Jr. (3181083), Mary V. Relling (47096), Kelli L. Boyd (245348), Amy J. Funk (3181086), Jitesh D. Kawedia (384551), Chengcheng Liu (402506), Laura J. Janke (780957), Laura B. Ramsey (780956)   +8 more
core   +1 more source