Results 91 to 100 of about 4,368 (233)

Non‐pituitary growth hormone enables colon cell senescence evasion

Aging Cell, Volume 23, Issue 8, August 2024.
Growth hormone (GH), stimulated by DNA damage and CXCL1, is induced in senescent cells and is a component of senescence‐associated secretory phenotype (SASP). SASP GH triggers senescence evasion in a subset of senescence cells and activates epithelial‐to‐mesenchymal transition (EMT), resulting in post‐senescent cell migration and transformation ...
Vera Chesnokova, Svetlana Zonis, Tugce Apaydin, Robert Barrett, Shlomo Melmed   +4 more
wiley   +1 more source

SAT-092 Disease-Specific Mortality in Patients With Acromegaly Treated With Pegvisomant - An ACROSTUDY Analysis [PDF]

J Endocr Soc
Disclosure: N.A. Tritos: None. M.O. Carlsson: Pfizer, Inc. G. Vila: Takeda, Lundbeck, Recordati, Ascendis, Novo Nordisk, Pharmanovia, Pfizer, Inc., HRA Pharmaceuticals, Merck. C. Jimenez: None. D. La Torre: Pfizer srl. M.P. Wajnrajch: Pfizer, Inc.
N. Tritos, M. Carlsson, G. Vila, Camilo Jimenez, Daria La Torre, M. Wajnrajch, Beverly MK Biller, Lissette Céspedes, K. Miller   +8 more
europepmc   +2 more sources

Improving quality of life in patients with pituitary tumours [PDF]

, 2017
Evaluation of health-related quality of life (QoL) in people with pituitary tumours has received much attention over the last 10-15 years. Most of them show impaired QoL, but little is known about how to prevent impairment or how to improve QoL.
Crespo, Iris, Martínez Momblán, Ma. Antonia, Resmini, Eugenia, Santos Vives, Alicia, Valassi, Elena, Webb, S. M. (Susan M.), 1952-   +5 more
core   +1 more source

18F‐fluoro‐ethyl‐tyrosine PET co‐registered with MRI in patients with persisting acromegaly

Clinical Endocrinology, Volume 101, Issue 2, Page 142-152, August 2024.
Abstract Objective To report our experience with 18F‐fluoro‐ethyl‐tyrosine (FET) positron emission tomography‐computed tomography (PET‐CT) co‐registered with magnetic resonance imaging (MRI) (FET‐PET/MRICR) in the care trajectory for persistent acromegaly. Design Prospective case series.
Leontine E. H. Bakker, Marco J. T. Verstegen, Diandra C. Manole, Huangling Lu, Thomas J. M. Decramer, Iris C. M. Pelsma, Mark C. Kruit, Berit M. Verbist, Annenienke van de Ven, Mark Gurnell, Idris Ghariq, Wouter R. van Furth, Nienke R. Biermasz, Lenka M. Pereira Arias‐Bouda   +13 more
wiley   +1 more source

Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.: Antinatriuretic action of growth hormone [PDF]

, 2008
International audienceAcromegalic patients present with volume expansion and arterial hypertension, but the renal sites and molecular mechanisms of direct antinatriuretic action of GH remain unclear.
Blanchard, Anne, Chanson, Philippe, Doucet, Alain, Imbert-Teboul, Martine, Kamenicky, Peter, Lombès, Marc, Meduri, Geri, Viengchareun, Say, Zizzari, Philippe   +8 more
core   +4 more sources

Guidelines on diagnostics and treatment of acromegaly (draft)

Ожирение и метаболизм
We recommend acromegaly to be ruled in all patients with characteristic changes in appearance (A3). In all patients without characteristic changes in appearance, we recommend to rule out acromegaly, if several clinical signs suspicious for acromegaly are
E. G. Przhiyalkovskaya, N. G. Mokrysheva, E. A. Troshina, G. A. Melnichenko, I. I. Dedov, M. B. Antsiferov, L. I. Astafieva, T. P. Bardymova, Zh. E. Belaya, G. R. Vagapova, S. Yu. Vorotnikova, A. Yu. Grigoriev, E. N. Grineva, L. K. Dzeranova, I. A. Ilovaiskaya, P. L. Kalinin, A. M. Lapshina, A. S. Lutsenko, E. O. Mamedova, E. I. Marova, M. A. Perepelova, E. A. Pigarova, V. S. Pronin, L. Ya. Rozhinskaya, Yu. Yu. Trunin, A. S. Shutova   +25 more
doaj   +1 more source

Visceral Adiposity Index Is Associated with Insulin Sensitivity and Adipocytokine Levels in Newly Diagnosed Acromegalic Patients. [PDF]

, 2012
Context: The visceral adiposity index (VAI) has proved to be a marker of visceral adipose dysfunction, strongly associated with insulin sensitivity in both the general and specific populations of patients at metabolic risk. Objective: The objective of
AMATO, Marco Calogero, CIRESI, Alessandro, GIORDANO, Carla, PIZZOLANTI, Giuseppe   +3 more
core   +1 more source

IGF‐1 as screening tool for acromegaly and adult‐onset growth hormone deficiency in the Netherlands

Clinical Endocrinology, Volume 100, Issue 3, Page 260-268, March 2024.
Abstract Objective Insulin‐like growth factor 1 (IGF‐1) measurements play a central role in the diagnosis and follow‐up of acromegaly and growth hormone deficiency. However, improving health care outcomes for these patients involves an intricate process of laboratory diagnostics and skilled health care professionals.
Mark R. Postma, André P. van Beek, Melanie M. van der Klauw, Eef G. W. M. Lentjes, Anneke C. Muller Kobold   +4 more
wiley   +1 more source

Prevención del cáncer mediante el control del factor de crecimiento insulínico tipo I. [PDF]

, 2016
Para prevenir el cáncer de forma eficaz es importante conocer cómo se origina y cómo se desarrolla la enfermedad. Evidencias recientes indican que este proceso se origina en las células madre y que el principal motivo biológico del cáncer es la ...
Medina Guerrero, Ana
core  

Pregnancy and acromegaly [PDF]

, 2016
Introduction: Acromegaly is a rare disorder in which, due to the high incidence of secondary hypogonadism, pregnancies are relatively rare. However, some women with acromegaly do get pregnant, which brings along questions about medication, complications ...
Lely, A-J. (Aart-Jan) van der, Muhammad, A. (Ammar), Neggers, S.J.C.M.M. (Bas)   +2 more
core   +1 more source