Results 11 to 20 of about 3,554 (229)

Pegvisomant and current approaches to the medical treatment of acromegaly (literature review and case report)

Ожирение и метаболизм, 2019
This review provides the main results of clinical trials and the literature on the experience of using pegvisomant, the first drug from the class of growth hormone receptor antagonists.
Larisa K. Dzeranova, Alexandra A. Povaliaeva, Anastasia A. Romanova, Elena G. Przhiyalkovskaya, Ekaterina A. Pigarova, Natalia S. Fedorova   +5 more
doaj   +3 more sources

GH receptor polymorphisms guide second-line therapies to prevent acromegaly skeletal fragility: preliminary results of a pilot study [PDF]

Frontiers in Endocrinology
BackgroundSkeletal fragility is characterized by increased frequency of vertebral fractures (VFs) in acromegaly. Several trials were conducted to identify modifiable risk factors and predictors of VFs, with limited data on the prognostic role of GH ...
Sabrina Chiloiro, Sabrina Chiloiro, Flavia Costanza, Flavia Costanza, Antonella Giampietro, Antonella Giampietro, Amato Infante, Pier Paolo Mattogno, Pier Paolo Mattogno, Flavia Angelini, Flavia Angelini, Consolato Gullì, Liverana Lauretti, Liverana Lauretti, Mario Rigante, Alessandro Olivi, Alessandro Olivi, Laura De Marinis, Laura De Marinis, Francesco Doglietto, Francesco Doglietto, Antonio Bianchi, Antonio Bianchi, Alfredo Pontecorvi, Alfredo Pontecorvi   +24 more
doaj   +2 more sources

Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity [PDF]

Frontiers in Endocrinology
Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects.
Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui   +12 more
doaj   +2 more sources

Pegvisomant Treatment in Acromegaly [PDF]

Neuroendocrinology, 2015
Historically, medical treatment of acromegaly has mainly been used as an adjuvant therapy after surgery. In the last decades, an increased range of medical therapy options has been available. Somatostatin analogues have become the cornerstones of medical treatment in acromegaly and are even seen as a primary treatment in a selected group of acromegaly ...
Sebastian Neggers, Ammar Muhammad, Aart Jan van der Lely   +2 more
openalex   +4 more sources

Safe Continuation of Pegvisomant During Pregnancy in a Patient With Fibrous Dysplasia/McCune-Albright Syndrome. [PDF]

JCEM Case Rep
Tan JY, Chemmanam J, Burt MG, Nguyen HTT, Ho JT.   +4 more
europepmc   +3 more sources

Pegvisomant [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Growth hormone receptor antagonists, GHA2 and GHA3, with dual activity against the human and mouse receptor. [PDF]

Protein Sci
Abstract Aberrant human growth hormone (GH) expression has been increasingly linked to poor outcomes in certain cancers and reduced health span. GH receptor (GHR) signal transduction activates signaling pathways that promote cell proliferation and survival, contributing to tumor progression.
Wang Y, Langley RJ, Harms J, Portlock T, Jamieson SMF, Perry JK.   +5 more
europepmc   +2 more sources

Pegvisomant

Reactions Weekly, 2006
europepmc   +3 more sources

Blockade of growth hormone receptor signaling by using pegvisomant: A functional therapeutic strategy in hepatocellular carcinoma

Frontiers in Oncology, 2022
Hepatocellular carcinoma (HCC) is an aggressive neoplasm with poor clinical outcome because most patients present at an advanced stage, at which point curative surgical options, such as tumor excision or liver transplantation, are not feasible. Therefore,
Ahmed O. Kaseb, Abedul Haque, Deeksha Vishwamitra, Manal M. Hassan, Lianchun Xiao, Bhawana George, Vishal Sahu, Yehia I. Mohamed, Roberto Carmagnani Pestana, Jamie Lynne Lombardo, Rony Avritscher, James C. Yao, Robert A. Wolff, Asif Rashid, Jeffrey S. Morris, Hesham M. Amin, Hesham M. Amin   +16 more
doaj   +1 more source

The place of medical treatment of acromegaly in Serbia: Current status [PDF]

Vojnosanitetski Pregled, 2021
nema
Doknić Mirjana, Stojanović Marko
doaj   +1 more source