Results 211 to 220 of about 4,368 (233)

The nuclear-localized GHR is involved in the cell proliferation of gastric cancer, and pegvisomant may be an important potential drug to inhibit the proliferation of gastric cancer cells.

Biochemistry and cell biology = Biochimie et biologie cellulaire, 2022
Under normal physiological conditions, growth hormones (GH) play an important role in body growth and metabolism. A recent study showed that GH has important biological effects on gastric cancer (GC) both in vitro and in vivo.
Yuanpu Meng, Bo Zhou, Z. Pei, Ye Chen, D. Chang   +4 more
semanticscholar   +1 more source

Pegvisomant or pasirotide in PRL and GH co-secreting vs GH-secreting Pit-NETs.

Endocrine-Related Cancer
AIM To evaluate the efficacy of second-line therapies in patients with acromegaly caused by a growth hormone (GH) and prolactin (PRL) co-secreting pituitary neuroendocrine tumor (GH/PRL-Pit-NET) and compare to those caused by a GH-Pit-NET.
M. Araujo-Castro, B. Biagetti, Edelmiro Menedez-Torre, Iría Novoa-Testa, Fernando Cordido, E. Pascual-Corrales, V. Rodríguez Berrocal, F. Guerrero-Pérez, Almudena Vicente, Juan Carlos Percovich Hualpa, R. García Centeno, Laura González Fernández, M. D. Ollero García, Ana Irigaray Echarri, M. D. Moure Rodríguez, C. Novo-Rodríguez, María Calatayud, Rocío Villar, I. Bernabéu, C. Álvarez-Escolá, Pamela Benítez Valderrama, Carmen Tenorio, P. Abellán Galiana, Eva Venegas, Inmaculada González-Molero, Pedro Iglesias, Concepción Blanco-Carrera, Fernando Vidal-Ostos de Lara, P. de Miguel Novoa, Elena López Mezquita, F. Hanzu, I. Aldecoa, Silvia Aznar, Cristina Lamas, A. Aulinas, Anna Queralt Asla, P. Gracia Gimeno, José María Recio Córdova, Mariola Aviles, Diego Asensio-Wandosel, M. Sampedro-Núñez, R. Cámara, Miguel Paja Fano, I. Ruz-Caracuel, C. Fajardo, Mónica Marazuela, Manel Puig-Domingo   +46 more
semanticscholar   +1 more source

The Role of the GH Receptor Polymorphisms as a Prognostic Factor of Vertebral Fractures in Acromegalic Patients Resistant to First-generation SSAs and Treated with Pegvisomant or Pasireotide LAR.

Endocrine, Metabolic & Immune Disorders - Drug Targets
BACKGROUND Acromegaly is associated with skeletal fragility and increased prevalence of vertebral fractures (VF). Two isoforms of GH receptor (GHR) have been described, which differ in the presence or absence of a transcript of exon 3 of the GHR gene ...
F. Costanza, S. Chiloiro, A. Giampietro, Flavia Angelini, A. Infante, A. Pontecorvi, L. De Marinis, Antonio Bianchi   +7 more
semanticscholar   +1 more source

The Combination Therapy of Pasireotide LAR Plus Pegvisomant and Cabergoline Relieved Acromegaly-Related Headache in a Female Patient with AIP-Mutated Acromegaly: A Case Report.

Endocrine, Metabolic & Immune Disorders - Drug Targets
INTRODUCTION Acromegaly is a rare condition characterized by excessive exposure to GH and IGF-1 due to a pituitary adenoma in most cases. The disease is associated with numerous symptoms, including headaches, which are frequently difficult to manage ...
Penelope Giambò, S. Chiloiro, A. Giampietro, P. Mattogno, L. Lauretti, L. De Marinis, Antonio Bianchi, Francesco Doglietto, A. Pontecorvi   +8 more
semanticscholar   +1 more source

The direct impact of pegvisomant on osteoblast functions and bone development

Journal of Endocrinological Investigation, 2023
E. Vitali, A. Grasso, M. L. Schiavone, G. Trivellin, C. Sobacchi, M. Mione, G. Mazziotti, A. Lania   +7 more
semanticscholar   +1 more source