Results 91 to 100 of about 22,067 (275)
Non-covalent PEGylation of therapeutic proteins
, 2016 Cette thèse en sciences pharmaceutiques se penchait sur la stabilisation des protéines thérapeutiques en solutions. Cette classe de médicaments possède quelques avantages par rapport aux petites molécules.
Reichert, Christian
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Advanced Intelligent Discovery, EarlyView.Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova +4 more
wiley +1 more source
, 2015 Poly(lactic acid) (PLA) has attracted growing attention as a sustainable and environmentally benign membrane material. The good biocompatibility/hemocompatibility is essential for hemodialysis membranes.
Liu, Fu +5 more
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PharmaceuticsBackground: Graphene Oxide (GO) has shown great potential in biomedical applications for cancer therapeutics. The biosafety and stability issues of GO in biological media have been addressed by functionalization with polyethylene glycol (PEG).
Athina Angelopoulou +6 more
doaj +1 more source
Drug Delivery, 2019 The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug nanoparticles (NPs), but rapid NPs aggregation in plasma greatly restricted their direct use for intravenous chemotherapy.
Jun Zeng +9 more
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International Journal of Nanomedicine, 2019 Yee Huang,1 Li Nan,1,2 Chenwen Xiao,1 Quanan Ji,1 Ke Li,1 Qiang Wei,1 Yan Liu,1 Guolian Bao1 1Institute of Animal Husbandry and Veterinary Medicine, Zhejiang Academy of Agricultural Science, Hangzhou 310021, People’s Republic of China; 2Zhejiang ...
Huang Y +7 more
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Mechanistic Insights into the Stabilization of srcSH3 by PEGylation
, 2016 Protein PEGylation (attaching PEG chains to proteins) has been widely used in pharmaceuticals and nanotechnology. Although it is widely known that PEGylation can increase the thermodynamic stability of proteins, the underlying mechanism remains elusive ...
Wei Meng (505670) +5 more
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PEGylation in anti-cancer therapy: An overview [PDF]
, 2016 Advanced drug delivery systems using poly(ethylene glycol) (PEG) is an important development in anti-cancer therapy. PEGylation has the ability to enhance the retention time of the therapeutics like proteins, enzymes small molecular drugs, liposomes and ...
Prajna Mishra +5 more
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Comparison of PEGylated and non-PEGylated proticles: An in vitro and in vivo study
European Journal of Pharmaceutical Sciences, 2019 The development of so-called Proticles opens attractive possibilities for new drug delivery systems. Proticles are nanoparticles (NPs), which are formed by self-assembly of negatively charged oligonucleotides in combination with the positively charged peptide protamine.
Katja Fresacher +9 more
openaire +2 more sources
Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy
, 2018 Haitao Pan,1,2 Jiayu Liu,1,2 Wentong Deng,1,2 Jieyu Xing,1,2 Qing Li,1,2 Zhong Wang1,2 1School of Pharmaceutical Sciences, 2Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, People’s Republic of China Introduction ...
Pan H +5 more
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